BNIP3L Antibody (S01-0F5)

Name: BNIP3L Antibody (S01-0F5)
Brand: Novus Biologicals
SKU: NBP3-19585
Price: 559 USD
Availability: InStock

Novus Biologicals | Catalog # NBP3-19585

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Product Documents

Recombinant Monoclonal Antibody

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S01-0F5 expressed in HEK293

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Product Specifications

Immunogen

A synthetic peptide of human BNIP3L (Uniprot # O60238)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

38 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for BNIP3L Antibody (S01-0F5)

Western Blot: BNIP3L Antibody (S01-0F5) [NBP3-19585]

Western Blot: BNIP3L Antibody (S01-0F5) [NBP3-19585] - Western blot detection of BNIP3L in Jurkat cell lysates using NBP3-19585 (1:500 diluted). Predicted band size: 24kDa. Observed band size: 38kDa.

Immunohistochemistry-Paraffin: BNIP3L Antibody (S01-0F5) [NBP3-19585]

Immunohistochemistry-Paraffin: BNIP3L Antibody (S01-0F5) [NBP3-19585] - Immunohistochemistry of BNIP3L in paraffin-embedded Human lung cancer tissue using NBP3-19585 at dilution 1/50

Applications for BNIP3L Antibody (S01-0F5)

Application

Recommended Usage

Immunohistochemistry

1/20-1/100

Western Blot

1/1000-1/5000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

0.3 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: BNIP3L

Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, Hrk, Nip3, and Bim, form a growingsubclass of the Bcl-2 family. A novel BH3 domaincontaining protein was recently identified and designated Bnip3L, Bnip3a, and Nix (for Nip3-like protein X) (Matsushima, M. et al.; Yasuda, M. et al.; Chen, G, et al.).Bnip3L/Bnip3a/Nix is a homolog of the E1B 19K/Bcl-2 binding and pro-apoptotic protein Bnip3. Over expression of Bnip3L induces apoptosis (Yasuda, M. et al.; Chen, G, et al.). Bnip3L interacts withand overcomes suppresses by Bcl-2 and Bcl-xL. Bnip3Lis localized in mitochondria. The messenger RNA of Bnip3L is ubiquitously expressed in human tissues (Matsushima, M. et al.; Yasuda, M. et al.). Bnip3L and Bnip3 form a new subfamily of the pro-apoptotic mitochondrial proteins.

Long Name

BCL2/Adenovirus E1B 19 Kda Protein-Interacting Protein 3-Like

Alternate Names

BNIP3a, Nip3L, Nix

Gene Symbol

BNIP3L

Additional BNIP3L Products

Product Documents for BNIP3L Antibody (S01-0F5)

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Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for BNIP3L Antibody (S01-0F5)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Autophagy

Bcl-2 Proteins and Regulators

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