Chemical Name: N-(Benzenesulfonyl)-L-prolyl-L-O-(1-pyrrolidinylcarbonyl)tyrosine sodium salt
Biological ActivityBOP is a dual α9β1/α4β1 integrin inhibitor; rapidly and preferentially mobilizes HSCs and progenitors. Augments HSC mobilization in combination with AMD3100 (Cat. No. 3299).
Fluorogenic, bright and photostable Fluorescent Conjugate BOP-JF646 (Cat. No. 6997) also available.
High affinity fluorescent derivative R-BC154 (Cat. No. 6048) also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist.
Cao et al.
Design, synthesis and binding properties of a fluorescent α9β1/α4β1 integrin antagonist and its application as an in vivo probe for bone marrow haemopoietic stem cells.
Cao et al.
Comparative assessment of the ligand and metal ion binding properties of integrins α9β1 and α4β1.
Pepinsky et al.
Citations for BOP
The citations listed below are publications that use Tocris products. Selected citations for BOP include:
4 Citations: Showing 1 - 4
Plasma cell dynamics in the bone marrow niche.
Authors: David R Et al.
Cell Rep 2021;34:108733
Tenascin-C immobilizes infiltrating T lymphocytes through CXCL12 promoting breast cancer progression.
Authors: Jingping Et al.
EMBO Mol Med 2021;13:e13270
Tenascin-C Orchestrates an Immune-Suppressive Tumor Microenvironment in Oral Squamous Cell Carcinoma.
Authors: Uwe Et al.
Cancer Immunol Res 2020;8:1122-1138
Intravital imaging reveals motility of adult hematopoietic stem cells in the bone marrow niche
Authors: Upadhaya Et al.
Cell Stem Cell 2020;27:336
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