BOP

Key Product Details

Product Description

BOP is a dual α9β1/α4β1 integrin inhibitor; rapidly and preferentially mobilizes HSCs and progenitors. Augments HSC mobilization in combination with AMD3100 (Cat. No. 3299).

Fluorogenic, bright and photostable Fluorescent Conjugate BOP-JF646 (Cat. No. 6997) also available.

High affinity fluorescent derivative R-BC154 (Cat. No. 6048) also available.

Product Specifications for BOP

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BOP

The following data is based on the product molecular weight 537.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.86 mL	9.30 mL	18.60 mL
5 mM	0.37 mL	1.86 mL	3.72 mL
10 mM	0.19 mL	0.93 mL	1.86 mL
50 mM	0.04 mL	0.19 mL	0.37 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Pepinsky Comparative assessment of the ligand and metal ion binding properties of integrins α9β1 and α4β1. Biochemistry 2002 PMID: 12033947
• Cao Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist. Nat.Commun. 2016 PMID: 26975966
• Cao Design, synthesis and binding properties of a fluorescent α9β1/α4β1 integrin antagonist and its application as an in vivo probe for bone marrow haemopoietic stem cells. Org.Biomol.Chem. 2014 PMID: 24363056

Product Documents for BOP