Catalog Number: 1189
Biological Activity
Highly potent and selective ETB endothelin receptor agonist (Ki values are 0.18 and 970 nM at human ETB and ETA receptors respectively).
Technical Data
  • M.Wt:
    2006.35
  • Formula:
    C96H140N20O25S
  • Sequence:
    LMDKEAVYFAHLDIIW

    (Modifications: Leu-1 = N-terminal Ac)

  • Solubility:
    Soluble to 0.50 mg/ml in sodium bicarbonate (0.03M)
  • Storage:
    Desiccate at -20°C
  • CAS No:
    143113-45-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. [3H]-BQ-123, a highly specific and reversible radioligand for the endothelin ETA receptor subtype.
    Ihara et al.
    Eur.J.Pharmacol., 1995;274:1
  2. Effects of selective ETB-receptor stimulation on arterial, venous and capillary functions in cat skeletal muscle.
    Ekelund et al.
    Br.J.Pharmacol., 1994;112:887
  3. Pharmacological differences between rat and human endothelin B receptors.
    Reynolds et al.
    Biochem.Biophys.Res.Commun., 1995;209:506
  4. Distinct subdomains of human endothelin receptors determine their selectivity to endothelinA-selective antagonist and endothelinB-selective agonists.
    Sakamoto et al.
    J.Biol.Chem., 1993;268:8547
Citations:

The citations listed below are publications that use Tocris products. Selected citations for BQ-3020 include:

1 Citations: Showing 1 - 1

  1. Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors.
    Authors: Hamby Et al.
    Cell Death Dis 2012;32:14489

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