BRD 6989

Catalog # Availability Size / Price Qty
BRD 6989 | CAS No. 642008-81-9 | Cyclin-dependent Kinase Inhibitors
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Description: Cdk8 inhibitor; enhances IL-10 production

Chemical Name: 2-Amino-5,6,7,8-tetrahydro-6-methyl-4-(3-pyridinyl)-3-quinolinecarbonitrile

Product Details

Biological Activity

Binds and inhibits Cdk8 in complex with cyclin C (IC50 ~ 200 nM). Enhances IL-10 production in activated human and murine macrophages and dendritic cells (EC50 is approximately 1 μM for IL-10 production in bone marrow-derived dendritic cells). Also inhibits CDK19 in complex with cyclin C.

Technical Data

Soluble to 20 mM in DMSO
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells.
    Johannessen et al.
    Nat.Chem.Biol., 2017;13:1102

Product Datasheets

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