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BRD 6989

Catalog #: 6438 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6438/50
6438/10
BRD 6989 | CAS No. 642008-81-9 | Cyclin-dependent Kinase Inhibitors
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Description: Cdk8 inhibitor; enhances IL-10 production

Chemical Name: 2-Amino-5,6,7,8-tetrahydro-6-methyl-4-(3-pyridinyl)-3-quinolinecarbonitrile

Purity: ≥98%

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Biological Activity

Binds and inhibits Cdk8 in complex with cyclin C (IC50 ~ 200 nM). Enhances IL-10 production in activated human and murine macrophages and dendritic cells (EC50 is approximately 1 μM for IL-10 production in bone marrow-derived dendritic cells). Also inhibits CDK19 in complex with cyclin C.

Technical Data

M.Wt:
264.33
Formula:
C16H16N4
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
642008-81-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells.
    Johannessen et al.
    Nat.Chem.Biol., 2017;13:1102

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