BRD PHOTAC-I-3

Tocris Bioscience | Catalog # 7319

Photoswitchable BET bromodomain Degrader (PHOTAC)
Tocris Bioscience
Discontinued Product
7319 has been discontinued. View all Active Degraders products.

Key Product Details

Description

Photoswitchable BET bromodomain Degrader (PHOTAC)
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Product Description

BRD PHOTAC-I-3 is a photoswitchable BET bromodomain degrader (PHOTAC, PHOtochemically TArgeting Chimera). BRD PHOTAC-I-3 comprises a ligand for an E3 ligase, a photoswitch, and the BET bromodomain targeting ligand (+)-JQ1 (Cat. No. 4499). Exhibits cytotoxicity and degrades BRD4, BRD3 and to a lesser extent BRD2 in lymphoblast cells upon irradiation with 390 nm light, but not in the dark. BRD2 antibodies validated for Western Blot also available: Catalog # NBP1-30475 and NBP2-75422.

Licensing Information

Sold under license from New York University

Product Specifications for BRD PHOTAC-I-3

Molecular Weight

935.45

Formula

C46H47ClN10O8S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f]-[1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-(2-(4-((E)-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)diazenyl)-2,6-dimethoxyphenoxy)acetamido)butyl)acetamide

CAS Number

2370997-94-5

PubChem ID

154722038

InChI Key

SGZZPSOQAWRZGE-RCBZUBGNSA-N

SMILES

COC1=CC(/N=N/C2=C3CN(C(C3=CC=C2)=O)C4CCC(NC4=O)=O)=CC(OC)=C1OCC(NCCCCNC(C[C@@H]5N=C(C6=CC=C(C=C6)Cl)C7=C(N8C(C)=NN=C58)SC(C)=C7C)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.77 50

Preparing Stock Solutions for BRD PHOTAC-I-3

The following data is based on the product molecular weight 935.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 2.14 mL 10.69 mL 21.38 mL
2.5 mM 0.43 mL 2.14 mL 4.28 mL
5 mM 0.21 mL 1.07 mL 2.14 mL
25 mM 0.04 mL 0.21 mL 0.43 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for BRD PHOTAC-I-3

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BRD PHOTAC-I-3

For research use only

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