Catalog Number: 1133
Chemical Name: 2-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-1H-isoindole maleate
Biological Activity
Selective α2A-adrenoceptor antagonist (Ki = 1.7 nM and 144.5 nM at α2A and α2B-adrenergic receptors respectively). Increases hippocampal noradrenalin release following systemic administration. Also available as part of the α2-Adrenoceptor Tocriset™.
Technical Data
  • M.Wt:
    331.37
  • Formula:
    C13H17N3.C4H4O4
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >98%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    681806-46-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of GlaxoSmithKline
Background References
  1. α2A-But not α2B/C-adrenoceptors modulate noradrenaline release in rat locus coeruleus: voltammetric data.
    Callado et al.
    Eur.J.Pharmacol., 1999;366:35
  2. α2C-adrenoceptors mediate contractile responses to noradrenaline in the human saphenous vein.
    Gavin et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 1997;355:406
  3. Subtype-specificity of the presynaptic α2-adrenoceptors modulating hippocampal norepinephrine release in rat.
    Kiss et al.
    Brain Res., 1995;674:238
  4. Novel α2-adrenoceptor antagonists show selectivity for α2A- and α2B-adrenoceptor subtypes.
    Young et al.
    Eur.J.Pharmacol., 1989;168:381
Citations:

The citations listed below are publications that use Tocris products. Selected citations for BRL 44408 maleate include:

1 Citations: Showing 1 - 1

  1. Alpha-2 adrenergic stimulation triggers Achilles tenocyte hypercellularity: Comparison between two model systems.
    Authors: Backman Et al.
    Scand J Med Sci Sports 2013;23:687

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