Chemical Name: (5'a)-2-Bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)ergotaman-3',6',18-trione mesylate
Biological ActivityBromocriptine mesylate is a selective D3 and D2 dopamine receptor agonist (Ki values are ~ 5 nM and ~ 8 nM respectively). Activates both isoforms of D2 receptor (EC50 values are 0.10-0.12 nM and 4.4 nM for D2L and D2S receptors, respectively. Bromocriptine shows anti-Aβ effects that are increased in combination with Cromolyn (Cat. No. 6424) and Topiramate (Cat. No. 3620). Also lowers glucose and increases insulin sensitivity in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Bromocriptine produces decreases in cocaine self-administration in the rat.
Aubner et al.
Bromocriptine in Parkinson disease.
Lieberman and Goldstein
DA receptor pharmacology.
Seeman and Van Tol
Trends Pharmacol.Sci., 1994;15:264
The effects of chronic bromocri. treatment on behaviour and DA receptor binding in the rat striatum.
Traub et al.
Citations for Bromocriptine mesylate
The citations listed below are publications that use Tocris products. Selected citations for Bromocriptine mesylate include:
3 Citations: Showing 1 - 3
A novel luminescence-based-β-arrestin recruitment assay for unmodified receptors.
Authors: Pedersen Et al.
J Biol Chem 2021;296:100503
Identification and validation of the DA agonist bromocri. as a novel therapy for high-risk myelodysplastic syndromes and secondary acute myeloid leukemia.
Authors: Liberante Et al.
Age-dependent regulation of synaptic connections by DA D2 receptors.
Authors: Jia Et al.
Nat Neurosci 2013;16:1627
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