Chemical Name: N-[2-[2-[2-[2-[4-[6-[(6-Acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]ethoxy]ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide
Biological ActivitySelective Cdk6 Degrader (PROTAC®) (DC50 in sub 10 μM range). Displays no degradation of closely related Cdk4.
Negative control BSJ-Bump (Cat. No. 6922) also available.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Homolog-selective degradation as a strategy to probe the function of CDK6 in AML.
Brand et al.
Cell Chem.Biol., 2019;26:300
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