BSJ-03-123

Catalog # Availability Size / Price Qty
6921/5
BSJ-03-123 | CAS No. 2361493-16-3 | Active Degraders
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Description: Selective Cdk6 degrader

Chemical Name: N-[2-[2-[2-[2-[4-[6-[(6-Acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]ethoxy]ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide

Purity: ≥98%

Product Details
Reviews

Biological Activity

Selective Cdk6 degrader (DC50 in sub 10 μM range). Displays no degradation of closely related Cdk4.

Negative control BSJ-Bump (Cat. No. 6922) also available.

Technical Data

M.Wt:
937.02
Formula:
C47H56N10O11
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2361493-16-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Dana-Farber Cancer Institute

Background References

  1. Homolog-selective degradation as a strategy to probe the function of CDK6 in AML.
    Brand et al.
    Cell Chem.Biol., 2019;26:300

Product Datasheets

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Reconstitution Calculator

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