BSJ-03-204

Tocris Bioscience | Catalog # 6938

Selective Cdk4/6 Degrader (PROTAC®
Tocris Bioscience

Key Product Details

Description

Selective Cdk4/6 Degrader (PROTAC®
View all Active Degraders »

Product Description

BSJ-03-204 is a selective Cdk4/6 Degrader (PROTAC®). Displays cereblon-dependent degradation with no effect on IKZF1/3 in Molt4 cells. Induces degradation of Cdk4/6 and G1 cell cycle arrest, and inhibits cell proliferation in a mantle cell lymphoma (MCL) cell line.

CDK4 antibodies validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF5254 and NBP1-31308.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from Dana-Farber Cancer Institute

Product Specifications for BSJ-03-204

Molecular Weight

832.92

Formula

C43H48N10O8

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-[4-[4-[6-[(6-Acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]butyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide

CAS Number

2349356-09-6

SMILES

CC1=C(C(N(C2=C1C=NC(NC3=CC=C(C=N3)N4CCN(CC4)CCCCNC(COC5=C6C(C(N(C6=O)C7C(NC(CC7)=O)=O)=O)=CC=C5)=O)=N2)C8CCCC8)=O)C(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 16.66 20

Preparing Stock Solutions for BSJ-03-204

The following data is based on the product molecular weight 832.92.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 6.00 mL 30.01 mL 60.03 mL
1 mM 1.20 mL 6.00 mL 12.01 mL
2 mM 0.60 mL 3.00 mL 6.00 mL
10 mM 0.12 mL 0.60 mL 1.20 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for BSJ-03-204

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BSJ-03-204

For research use only

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