Catalog # Availability Size / Price Qty
BSJ-03-204 | CAS No. 2349356-09-6 | Active Degraders
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Description: Selective Cdk4/6 Degrader (PROTAC®

Chemical Name: N-[4-[4-[6-[(6-Acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]butyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide

Purity: ≥98%

Product Details
Citations (1)

Biological Activity

BSJ-03-204 is a selective Cdk4/6 Degrader (PROTAC®). Displays cereblon-dependent degradation with no effect on IKZF1/3 in Molt4 cells. Induces degradation of Cdk4/6 and G1 cell cycle arrest, and inhibits cell proliferation in a mantle cell lymphoma (MCL) cell line.

CDK4 antibodies validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF5254 and NBP1-31308.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

Soluble to 20 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Dana-Farber Cancer Institute

Background References

  1. Development of dual and selective degraders of cyclin-dependent kinases 4 and 6.
    Jiang et al.
    Angew.Chem.Int.Ed.Engl., 2019;58:6321

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Citation for BSJ-03-204

The citations listed below are publications that use Tocris products. Selected citations for BSJ-03-204 include:

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