BSJ-03-204

Catalog # Availability Size / Price Qty
6938/5
Active Degraders Small Molecule
1 Image
Description: Selective Cdk4/6 degrader

Chemical Name: N-[4-[4-[6-[(6-Acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]butyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide

Purity: ≥98%

Product Details
Reviews

Biological Activity

Selective Cdk4/6 degrader. Displays cereblon-dependent degradation with no effect on IKZF1/3 in Molt4 cells. Induces degradation of Cdk4/6 and G1 cell cycle arrest, and inhibits cell proliferation in a mantle cell lymphoma (MCL) cell line.

Technical Data

M.Wt:
832.92
Formula:
C43H48N10O8
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2349356-09-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Dana-Farber Cancer Institute

Background References

  1. Development of dual and selective degraders of cyclin-dependent kinases 4 and 6.
    Jiang et al.
    Angew.Chem.Int.Ed.Engl., 2019;58:6321

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