BTD S-sulfenic acid probe

Key Product Details

Product Description

BTD S-sulfenic acid probe is a nucleophilic fragment that can selectively modify sulfenic acid residues in proteins, and can be used as a tool to identify ligandable S-sulfenation sites. Covalently modifies oxidized cysteines on proteins. Quantitatively labels hyper-reactive sulfenic acids at low BTD concentrations, less reactive sites exhibit concentration-dependent increases in probe labeling. Incorporates an alkyne handle for click chemistry and chemoproteomic profiling.

Optical Data

Product Specifications for BTD S-sulfenic acid probe

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BTD S-sulfenic acid probe

The following data is based on the product molecular weight 263.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.80 mL	18.99 mL	37.98 mL
5 mM	0.76 mL	3.80 mL	7.60 mL
10 mM	0.38 mL	1.90 mL	3.80 mL
50 mM	0.08 mL	0.38 mL	0.76 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Gupta Diverse redoxome reactivity profiles of carbon nucleophiles. J.Am.Chem.Soc. 2017 PMID: 28355876
• Fu Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat.Chem.Biol. 2023 PMID: 37248412

Product Documents for BTD S-sulfenic acid probe