Chemical Name: 2-(2-Pyridinyl)-4H-1,3-benzothiazin-4-one
Biological ActivityMacrophage migration inhibitory factor (MIF) binder (Kd = 68.6 nM). Activates antioxidant response element (ARE)-mediated gene expression. Suppresses oxidative stress-induced cardiomyocyte apoptosis in vitro. Cardioprotective.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
BTZO-1, a cardioprotective agent, reveals that macrophage migration inhibitor factor regulates ARE-mediated gene expression.
Kimura et al.
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