BTZO 1

Key Product Details

Product Description

BTZO 1 binds macrophage migration inhibitory factor (MIF; K_d = 68.6 nM) and activates antioxidant response element (ARE)-mediated gene expression. BTZO 1 suppresses oxidative stress-induced cardiomyocyte apoptosis in vitro and is cardioprotective.

External Portal Information

Chemicalprobes.org

and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of BTZO 1 is reviewed on chemicalprobes.org and the SGC website.

Product Specifications for BTZO 1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BTZO 1

The following data is based on the product molecular weight 240.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	20.81 mL	104.05 mL	208.09 mL
1 mM	4.16 mL	20.81 mL	41.62 mL
2 mM	2.08 mL	10.40 mL	20.81 mL
10 mM	0.42 mL	2.08 mL	4.16 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Kimura BTZO-1, a cardioprotective agent, reveals that macrophage migration inhibitor factor regulates ARE-mediated gene expression. Chem.Biol. 2010 PMID: 21168764

Product Documents for BTZO 1