Catalog Number: 3108
Chemical Name: 3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid
Biological Activity
Loop diuretic that inhibits the Na+/2Cl-/K+ (NKCC) cotransporter. More potent than furosemide (Cat. No. 3109).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 75 mM in ethanol
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Characteristics and functions of Na-K-Cl cotransport in epithelial tissues.
    O'Grady et al.
    Am.J.Physiol., 1987;253:C177
  2. Ion and bumetanide binding by the Na-K-Cl cotransporter.
    Isenring and Forbush
    J.Biol.Chem., 1997;272:24556
  3. Functional evidence for involvement of bumetanide-sensitive Na+K+2Cl- cotransport in the hepatoportal Na+ receptor of the sprague-dawley rat.
    Morita et al.
    Neurosci.Letts., 1999;264:65
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