Chemical Name: 3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid
Biological ActivityLoop diuretic that inhibits the Na+/2Cl-/K+ (NKCC) cotransporter. More potent than furosemide (Cat. No. 3109).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Characteristics and functions of Na-K-Cl cotransport in epithelial tissues.
O'Grady et al.
Functional evidence for involvement of bumetanide-sensitive Na+K+2Cl- cotransport in the hepatoportal Na+ receptor of the sprague-dawley rat.
Morita et al.
Ion and bumet. binding by the Na-K-Cl cotransporter.
Isenring and Forbush
Citations for Bumetanide
The citations listed below are publications that use Tocris products. Selected citations for Bumetanide include:
12 Citations: Showing 1 - 10
Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space.
Authors: Babola Et al.
Toxoplasma-Induced Hypermigration of Primary Cortical Microglia Implicates GABAergic Signaling.
Authors: Bhandage Et al.
Front Cell Infect Microbiol 2019;9:73
KCC2-Mediated Cl- Extrusion Modulates Spontaneous Hippocampal Network Events in Perinatal Rats and Mice.
Authors: Spoljaric Et al.
Cell Rep 2019;26:1073
Cl- out is a novel cooperative optogenetic tool for extruding chloride from neurons
Authors: Alfonsa Et al.
Nature Communications 2016;7:13495
Appearance of fast astrocytic component in voltage-sensitive dye imaging of neural activity.
Authors: Pál Et al.
High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons.
Authors: Choe Et al.
Mol Brain 2015;85:549
A role for intracellular zinc in glioma alteration of neuronal chloride equilibrium.
Authors: Angelantonio Et al.
Cell Death Dis 2014;5:e1501
Disrupted Cl(-) homeostasis contributes to reductions in the inhibitory efficacy of D.pam during hyperexcited states.
Authors: Deeb Et al.
Eur J Neurosci 2013;38:2453
GABA is excitatory in adult vasopressinergic neuroendocrine cells.
Authors: Haam Et al.
J Neurosci 2012;32:572
The loop diuretic bumet. blocks posttraumatic p75NTR upregulation and rescues injured neurons.
Authors: Shulga Et al.
J Neurosci 2012;32:1757
Low expression of Kv7/M channels facilitates intrinsic and network bursting in the developing rat hippocampus.
Authors: Safiulina Et al.
J Physiol 2008;586:5437
Posttraumatic GABA(A)-mediated [Ca2+]i increase is essential for the induction of brain-derived neurotrophic factor-dependent survival of mature central neurons.
Authors: Shulga Et al.
J Neurosci 2008;28:6996
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