Catalog Number: 3108
Chemical Name: 3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid
Biological Activity
Loop diuretic that inhibits the Na+/2Cl-/K+ (NKCC) cotransporter. More potent than furosemide (Cat. No. 3109).
Technical Data
  • M.Wt:
    364.42
  • Formula:
    C17H20N2O5S
  • Solubility:
    Soluble to 100 mM in DMSO and to 75 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    28395-03-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Characteristics and functions of Na-K-Cl cotransport in epithelial tissues.
    O'Grady et al.
    Am.J.Physiol., 1987;253:C177
  2. Ion and bumetanide binding by the Na-K-Cl cotransporter.
    Isenring and Forbush
    J.Biol.Chem., 1997;272:24556
  3. Functional evidence for involvement of bumetanide-sensitive Na+K+2Cl- cotransport in the hepatoportal Na+ receptor of the sprague-dawley rat.
    Morita et al.
    Neurosci.Letts., 1999;264:65
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Bumetanide include:

5 Citations: Showing 1 - 5
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  1. Cl- out is a novel cooperative optogenetic tool for extruding chloride from neurons
    Authors: Alfonsa Et al.
    Nature Communications 2016;7:13495
  2. Appearance of fast astrocytic component in voltage-sensitive dye imaging of neural activity.
    Authors: Pál Et al.
    Neuron 2015;8:35
  3. High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons.
    Authors: Choe Et al.
    Mol Brain 2015;85:549
  4. GABA is excitatory in adult vasopressinergic neuroendocrine cells.
    Authors: Haam Et al.
    J Neurosci 2012;32:572
  5. The loop diuretic bumetanide blocks posttraumatic p75NTR upregulation and rescues injured neurons.
    Authors: Shulga Et al.
    J Neurosci 2012;32:1757

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