Bumetanide

Key Product Details

Product Description

Bumetanide is a loop diuretic that inhibits the Na⁺/2Cl^-/K⁺ (NKCC) cotransporter. More potent than furosemide (Cat. No. 3109). Bumetanide improves electrophysiological, pathological and cognitive deficits in APOE4 knock-in mice. RNA sequencing of neurons derived from APOE4 induced pluripotent stem cell (iPSC) shows Bumetanide reverses Alzheimer's disease transcriptomic signatures.

Product Specifications for Bumetanide

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Bumetanide

The following data is based on the product molecular weight 364.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.74 mL	13.72 mL	27.44 mL
5 mM	0.55 mL	2.74 mL	5.49 mL
10 mM	0.27 mL	1.37 mL	2.74 mL
50 mM	0.05 mL	0.27 mL	0.55 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 91 publications citing the usage of this product.

• Taubes Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4-related Alzheimer's disease. Nature Aging 2021 PMID: 36172600
• Isenring and Forbush Ion and bumet. binding by the Na-K-Cl cotransporter. J.Biol.Chem. 1997 PMID: 9305921
• Morita Functional evidence for involvement of bumetanide-sensitive Na⁺K⁺2Cl^- cotransport in the hepatoportal Na⁺ receptor of the sprague-dawley rat. Neurosci.Letts. 1999 PMID: 10320015
• O'Grady Characteristics and functions of Na-K-Cl cotransport in epithelial tissues. Am.J.Physiol. 1987 PMID: 3303961

Product Documents for Bumetanide