Chemical Name: 3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid
Biological ActivityBumetanide is a loop diuretic that inhibits the Na+/2Cl-/K+ (NKCC) cotransporter. More potent than furosemide (Cat. No. 3109). Bumetanide improves electrophysiological, pathological and cognitive deficits in APOE4 knock-in mice. RNA sequencing of neurons derived from APOE4 induced pluripotent stem cell (iPSC) shows Bumetanide reverses Alzheimer's disease transcriptomic signatures.
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Characteristics and functions of Na-K-Cl cotransport in epithelial tissues.
O'Grady et al.
Ion and bumet. binding by the Na-K-Cl cotransporter.
Isenring and Forbush
Citations for Bumetanide
The citations listed below are publications that use Tocris products. Selected citations for Bumetanide include:
12 Citations: Showing 1 - 10
Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space.
Authors: Babola Et al.
Toxoplasma-Induced Hypermigration of Primary Cortical Microglia Implicates GABAergic Signaling.
Authors: Bhandage Et al.
Front Cell Infect Microbiol 2019;9:73
KCC2-Mediated Cl- Extrusion Modulates Spontaneous Hippocampal Network Events in Perinatal Rats and Mice.
Authors: Spoljaric Et al.
Cell Rep 2019;26:1073
Cl- out is a novel cooperative optogenetic tool for extruding chloride from neurons
Authors: Alfonsa Et al.
Nature Communications 2016;7:13495
Appearance of fast astrocytic component in voltage-sensitive dye imaging of neural activity.
Authors: Pál Et al.
High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons.
Authors: Choe Et al.
Mol Brain 2015;85:549
A role for intracellular zinc in glioma alteration of neuronal chloride equilibrium.
Authors: Angelantonio Et al.
Cell Death Dis 2014;5:e1501
Disrupted Cl(-) homeostasis contributes to reductions in the inhibitory efficacy of D.pam during hyperexcited states.
Authors: Deeb Et al.
Eur J Neurosci 2013;38:2453
GABA is excitatory in adult vasopressinergic neuroendocrine cells.
Authors: Haam Et al.
J Neurosci 2012;32:572
The loop diuretic bumet. blocks posttraumatic p75NTR upregulation and rescues injured neurons.
Authors: Shulga Et al.
J Neurosci 2012;32:1757
Low expression of Kv7/M channels facilitates intrinsic and network bursting in the developing rat hippocampus.
Authors: Safiulina Et al.
J Physiol 2008;586:5437
Posttraumatic GABA(A)-mediated [Ca2+]i increase is essential for the induction of brain-derived neurotrophic factor-dependent survival of mature central neurons.
Authors: Shulga Et al.
J Neurosci 2008;28:6996
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