Bumetanide

Catalog # Availability Size / Price Qty
3108/50
Bumetanide | CAS No. 28395-03-1 | NKCC Cotransporter Inhibitors
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Description: Na+/2Cl-/K+ (NKCC) symporter inhibitor

Chemical Name: 3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid

Purity: ≥99%

Product Details
Citations (11)
Supplemental Products
Reviews

Biological Activity

Loop diuretic that inhibits the Na+/2Cl-/K+ (NKCC) cotransporter. More potent than furosemide (Cat. No. 3109).

Technical Data

M.Wt:
364.42
Formula:
C17H20N2O5S
Solubility:
Soluble to 100 mM in DMSO and to 75 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
28395-03-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Characteristics and functions of Na-K-Cl cotransport in epithelial tissues.
    O'Grady et al.
    Am.J.Physiol., 1987;253:C177
  2. Functional evidence for involvement of bumetanide-sensitive Na+K+2Cl- cotransport in the hepatoportal Na+ receptor of the sprague-dawley rat.
    Morita et al.
    Neurosci.Letts., 1999;264:65
  3. Ion and bumet. binding by the Na-K-Cl cotransporter.
    Isenring and Forbush
    J.Biol.Chem., 1997;272:24556

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Citations for Bumetanide

The citations listed below are publications that use Tocris products. Selected citations for Bumetanide include:

11 Citations: Showing 1 - 10

  1. Toxoplasma-Induced Hypermigration of Primary Cortical Microglia Implicates GABAergic Signaling.
    Authors: Bhandage Et al.
    Front Cell Infect Microbiol  2019;9:73
  2. KCC2-Mediated Cl- Extrusion Modulates Spontaneous Hippocampal Network Events in Perinatal Rats and Mice.
    Authors: Spoljaric Et al.
    Cell Rep  2019;26:1073
  3. Cl- out is a novel cooperative optogenetic tool for extruding chloride from neurons
    Authors: Alfonsa Et al.
    Nature Communications  2016;7:13495
  4. Appearance of fast astrocytic component in voltage-sensitive dye imaging of neural activity.
    Authors: Pál Et al.
    Neuron  2015;8:35
  5. High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons.
    Authors: Choe Et al.
    Mol Brain  2015;85:549
  6. A role for intracellular zinc in glioma alteration of neuronal chloride equilibrium.
    Authors: Angelantonio Et al.
    Cell Death Dis  2014;5:e1501
  7. Disrupted Cl(-) homeostasis contributes to reductions in the inhibitory efficacy of D.pam during hyperexcited states.
    Authors: Deeb Et al.
    Eur J Neurosci  2013;38:2453
  8. GABA is excitatory in adult vasopressinergic neuroendocrine cells.
    Authors: Haam Et al.
    J Neurosci  2012;32:572
  9. The loop diuretic bumet. blocks posttraumatic p75NTR upregulation and rescues injured neurons.
    Authors: Shulga Et al.
    J Neurosci  2012;32:1757
  10. Low expression of Kv7/M channels facilitates intrinsic and network bursting in the developing rat hippocampus.
    Authors: Safiulina Et al.
    J Physiol  2008;586:5437

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