Bumetanide

  ( 9 citations )    
Product Datasheet
Catalog Number:3108
Chemical Name:3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid
Product Details
Citations (9)
Supplemental Products
Reviews
Biological Activity
Loop diuretic that inhibits the Na+/2Cl-/K+ (NKCC) cotransporter. More potent than furosemide (Cat. No. 3109).
Technical Data
  • M.Wt:
    364.42
  • Formula:
    C17H20N2O5S
  • Solubility:
    Soluble to 100 mM in DMSO and to 75 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    28395-03-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Bumetanide include:

9 Citations: Showing 1 - 9
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  1. Cl- out is a novel cooperative optogenetic tool for extruding chloride from neurons
    Authors: Alfonsa Et al.
    Nature Communications  2016;7:13495
  2. Appearance of fast astrocytic component in voltage-sensitive dye imaging of neural activity.
    Authors: Pál Et al.
    Neuron  2015;8:35
  3. High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons.
    Authors: Choe Et al.
    Mol Brain  2015;85:549
  4. A role for intracellular zinc in glioma alteration of neuronal chloride equilibrium.
    Authors: Angelantonio Et al.
    Cell Death Dis  2014;5:e1501
  5. Disrupted Cl(-) homeostasis contributes to reductions in the inhibitory efficacy of diazepam during hyperexcited states.
    Authors: Deeb Et al.
    Eur J Neurosci  2013;38:2453
  6. GABA is excitatory in adult vasopressinergic neuroendocrine cells.
    Authors: Haam Et al.
    J Neurosci  2012;32:572
  7. The loop diuretic bumetanide blocks posttraumatic p75NTR upregulation and rescues injured neurons.
    Authors: Shulga Et al.
    J Neurosci  2012;32:1757
  8. Low expression of Kv7/M channels facilitates intrinsic and network bursting in the developing rat hippocampus.
    Authors: Safiulina Et al.
    J Physiol  2008;586:5437
  9. Posttraumatic GABA(A)-mediated [Ca2+]i increase is essential for the induction of brain-derived neurotrophic factor-dependent survival of mature central neurons.
    Authors: Shulga Et al.
    J Neurosci  2008;28:6996

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