Catalog Number: 3109
Chemical Name: 5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic acid
Biological Activity
Loop diuretic that inhibits the Na+/2Cl-/K+ (NKCC) symporter. Also acts as a non-competitive antagonist at GABAA receptors with ~ 100-fold greater selectivity for α6-containing receptors than α1-containing receptors.
Technical Data
  • M.Wt:
    330.74
  • Formula:
    C12H11ClN2O5S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    54-31-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Residues in transmembrane domains I and II determine γ-aminobutyric acid type AA receptor subtype-selective antagonism by furosemide.
    Thompson et al.
    Mol.Pharmacol., 1999;55:993
  2. Anticonvulsant actions of furosemide in vitro.
    Gutschmidt et al.
    Neuroscience, 1999;91:1471
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Furosemide include:

2 Citations: Showing 1 - 2
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  1. Dendritic cell amiloride-sensitive channels mediate sodium-induced inflammation and hypertension.
    Authors: Barbaro
    Cell?Rep 2017;21(4):1009
  2. High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons.
    Authors: Choe Et al.
    Autophagy 2015;85:549

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