Furosemide

  ( 5 citations )    
Product Datasheet
Catalog Number:3109
Chemical Name:5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic acid
Product Details
Citations (5)
Supplemental Products
Reviews
Biological Activity
Loop diuretic that inhibits the Na+/2Cl-/K+ (NKCC) symporter. Also acts as a non-competitive antagonist at GABAA receptors with ~ 100-fold greater selectivity for α6-containing receptors than α1-containing receptors.
Technical Data
  • M.Wt:
    330.74
  • Formula:
    C12H11ClN2O5S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    54-31-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Furosemide include:

5 Citations: Showing 1 - 5
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  1. Dendritic cell amiloride-sensitive channels mediate sodium-induced inflammation and hypertension.
    Authors: Barbaro
    Cell Rep  2017;21(4):1009
  2. High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons.
    Authors: Choe Et al.
    Autophagy  2015;85:549
  3. α6-Containing GABAA Receptors Are the Principal Mediators of Inhibitory Synapse Strengthening by Insulin in Cerebellar Granule Cells.
    Authors: Accardi Et al.
    J Neurosci  2015;35:9676
  4. A role for intracellular zinc in glioma alteration of neuronal chloride equilibrium.
    Authors: Angelantonio Et al.
    Cell Death Dis  2014;5:e1501
  5. Disrupted Cl(-) homeostasis contributes to reductions in the inhibitory efficacy of diazepam during hyperexcited states.
    Authors: Deeb Et al.
    Eur J Neurosci  2013;38:2453

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