BYK 191023 dihydrochloride

Catalog # Availability Size / Price Qty
2866/10
2866/50
BYK 191023 dihydrochloride | CAS No. 1216722-25-6 | iNOS Inhibitors
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Description: Potent and selective inhibitor of iNOS

Chemical Name: 2-[2-(4-Methoxy-2-pyridinyl)ethyl]-1H-imidazo[4,5-b]pyridine dihydrochloride

Purity: ≥99%

Product Details
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Biological Activity

Potent and selective inhibitor of inducible nitric oxide synthase (iNOS) (IC50 values are 86, 17000, 162000 nM for iNOS, nNOS and eNOS respectively). Acts in an NADPH- and time-dependent manner. Active in vivo, reverses pathological hypotension in the rodent endotoxin model.

Technical Data

M.Wt:
327.21
Formula:
C14H14N4O.2HCl
Solubility:
Soluble to 100 mM in water
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
1216722-25-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of Nycomed

Background References

  1. In vivo characterisation of the novel imidazopyridine BYK191023 2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine, a potent and highly selective inhibitor of inducible nitric-oxide synthase.
    Lehner et al.
    J.Pharmacol.Exp.Ther., 2006;317:181
  2. The novel imidazopyridine 2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine (BYK191023) is a highly selective inhibitor of the inducible nitric-oxide synthase.
    Strub et al.
    Mol.Pharmacol., 2006;68:328
  3. BYK191023 (2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine) is an NADPH- and time-dependent irreversible inhibitor of inducible nitric-oxide synthase.
    Tiso et al.
    Mol.Pharmacol., 2008;72:1244

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