BYK 191023 dihydrochloride
Chemical Name: 2-[2-(4-Methoxy-2-pyridinyl)ethyl]-1H-imidazo[4,5-b]pyridine dihydrochloride
Biological ActivityBYK 191023 dihydrochloride is a potent and selective inhibitor of inducible nitric oxide synthase (iNOS) (IC50 values are 86, 17000, 162000 nM for iNOS, nNOS and eNOS respectively). Acts in an NADPH- and time-dependent manner. Active in vivo, reverses pathological hypotension in the rodent endotoxin model.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
In vivo characterisation of the novel imidazopyridine BYK191023 2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine, a potent and highly selective inhibitor of inducible nitric-oxide synthase.
Lehner et al.
The novel imidazopyridine 2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine (BYK191023) is a highly selective inhibitor of the inducible nitric-oxide synthase.
Strub et al.
BYK191023 (2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine) is an NADPH- and time-dependent irreversible inhibitor of inducible nitric-oxide synthase.
Tiso et al.
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