Chemical Name: 7-Chloro-1,3-dihydro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthalenylmethyl)-2H-1,4-benzodiazepin-2-one
Biological ActivityBz 423 is an ATP synthase inhibitor (IC50 ~5 μM). Binds the oligomycin sensitivity conferring protein (OSCP) component of mitochondrial F1F0-ATPase in vitro resulting in generation of superoxide and apoptosis. Kills primary B and T cell in mice in vivo. Suppresses autoimmunity and prolongs survival in mouse lupus model.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Identification and validation of the mitochondrial F1F0-ATPase as the molecular target of the immunomodulatory benzodiazepine Bz-423.
Johnson et al.
Bz-423 superoxide signals B cell apoptosis via Mcl-1, Bak, and Bax.
Blatt et al.
Benzodiazepine-induced superoxide signals B cell apoptosis: mechanistic insight and potential therapeutic utility.
Blatt et al.
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