Catalog Number: 5791
Chemical Name: 7-Chloro-1,3-dihydro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthalenylmethyl)-2H-1,4-benzodiazepin-2-one
Biological Activity
ATP synthase inhibitor (IC50 ~5 μM). Binds the oligomycin sensitivity conferring protein (OSCP) component of mitochondrial F1F0-ATPase in vitro resulting in generation of superoxide and apoptosis. Kills primary B and T cell in mice in vivo. Suppresses autoimmunity and prolongs survival in mouse lupus model.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification and validation of the mitochondrial F1F0-ATPase as the molecular target of the immunomodulatory benzodiazepine Bz-423.
    Johnson et al.
    Chem.Biol., 2005;12:485
  2. Bz-423 superoxide signals B cell apoptosis via Mcl-1, Bak, and Bax.
    Blatt et al.
    Biochem.Pharmacol., 2009;15:966
  3. Benzodiazepine-induced superoxide signals B cell apoptosis: mechanistic insight and potential therapeutic utility.
    Blatt et al.
    J.Clin.Invest., 2002;110:1123
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