Bz 423

Catalog # Availability Size / Price Qty
5791/10
5791/50
Bz 423 | CAS No. 216691-95-1 | Synthase/Synthetase Inhibitors
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Description: ATP synthase inhibitor; proapoptotic

Chemical Name: 7-Chloro-1,3-dihydro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthalenylmethyl)-2H-1,4-benzodiazepin-2-one

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

Bz 423 is an ATP synthase inhibitor (IC50 ~5 μM). Binds the oligomycin sensitivity conferring protein (OSCP) component of mitochondrial F1F0-ATPase in vitro resulting in generation of superoxide and apoptosis. Kills primary B and T cell in mice in vivo. Suppresses autoimmunity and prolongs survival in mouse lupus model.

Technical Data

M.Wt:
440.92
Formula:
C27H21ClN2O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
216691-95-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for Bz 423

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