C 021 dihydrochloride
Chemical Name: 2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinamine dihydrochloride
Biological ActivityC 021 dihydrochloride is a potent CCR4 chemokine receptor antagonist (IC50 values are 0.14 and 0.039 μM for inhibition of chemotaxis in human and mouse respectively).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Potent and orally bioavailable CCR4 antagonists: synthesis and structure-activity relationship study of 2-aminoquinazolines.
Yokoyama et al.
Citations for C 021 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for C 021 dihydrochloride include:
5 Citations: Showing 1 - 5
CCR4 expression on host T cells is a driver for alloreactive responses and lung rejection.
Authors: Palchevskiy Et al.
JCI Insight 2019;5
CCL17/TARC and CCR4 expression in Merkel cell carcinoma.
Authors: Rasheed Et al.
Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues.
Authors: He Et al.
CCL2 Mediates Neuron-Macrophage Interactions to Drive Proregenerative Macrophage Activation Following Preconditioning Injury.
Authors: Kwon Et al.
J Neurosci 2015;35:15934
Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline.
Authors: McMillin Et al.
J Neuroinflammation 2014;11:121
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I used it both in vivo and in vitro. In vitro, I was unable to find any impact in chemotaxis towards CCL17