Catalog Number: 3581
Chemical Name: 2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinamine dihydrochloride
Biological Activity
Potent CCR4 chemokine receptor antagonist (IC50 values are 0.14 and 0.039 μM for inhibition of chemotaxis in human and mouse respectively).
Technical Data
  • M.Wt:
    540.57
  • Formula:
    C27H41N5O2.2HCl
  • Solubility:
    Soluble to 50 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    864289-85-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Potent and orally bioavailable CCR4 antagonists: synthesis and structure-activity relationship study of 2-aminoquinazolines.
    Yokoyama et al.
    Bioorg.Med.Chem., 2009;17:64
Citations:

The citations listed below are publications that use Tocris products. Selected citations for C 021 dihydrochloride include:

1 Citations: Showing 1 - 1

  1. Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline.
    Authors: McMillin Et al.
    J Neuroinflammation 2014;11:121

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