C 021 dihydrochloride

Tocris Bioscience | Catalog # 3581

Potent CCR4 antagonist
Tocris Bioscience

Key Product Details

Description

Potent CCR4 antagonist
View all Chemokine Receptor Antagonists »

Product Description

C 021 dihydrochloride is a potent CCR4 chemokine receptor antagonist (IC50 values are 0.14 and 0.039 μM for inhibition of chemotaxis in human and mouse respectively).

Product Specifications for C 021 dihydrochloride

Molecular Weight

540.57

Formula

C27H41N5O2.2HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinamine dihydrochloride

CAS Number

1784252-84-1

PubChem ID

56972238

InChI Key

GKJKNYQUFAPLOQ-UHFFFAOYSA-N

SMILES

COC1=C(OC)C=C(N=C(N4CCC(N5CCCCC5)CC4)N=C2NC3CCCCCC3)C2=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 26.96 50
DMSO 53.93 100

Preparing Stock Solutions for C 021 dihydrochloride

The following data is based on the product molecular weight 540.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.85 mL 9.25 mL 18.50 mL
5 mM 0.37 mL 1.85 mL 3.70 mL
10 mM 0.18 mL 0.92 mL 1.85 mL
50 mM 0.04 mL 0.18 mL 0.37 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 14 publications citing the usage of this product.

Product Documents for C 021 dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for C 021 dihydrochloride

For research use only

Citations for C 021 dihydrochloride

Customer Reviews for C 021 dihydrochloride (1)

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  • Unfortunately I found no effect.
    Name: Anonymous
    Species: Human
    Verified Customer | Posted 12/12/2017
    I used it both in vivo and in vitro. In vitro, I was unable to find any impact in chemotaxis towards CCL17

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