C 75

Key Product Details

Product Description

C 75 is a synthetic inhibitor of fatty acid synthase (FASN); inhibits fatty acid synthesis in vitro and in vivo. Displays anorectic effects. Induces apoptosis in MCF-7 xenografts and exhibits antitumor activity.

Product Specifications for C 75

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for C 75

The following data is based on the product molecular weight 254.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.93 mL	19.66 mL	39.32 mL
5 mM	0.79 mL	3.93 mL	7.86 mL
10 mM	0.39 mL	1.97 mL	3.93 mL
50 mM	0.08 mL	0.39 mL	0.79 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

• Thupari Chronic C75 treatment of diet-induced obese mice increases fat oxidation and reduces food intake to reduce adipose mass. Am.J.Physiol.Endocrinol.Metab.
• Takahashi The anorexigenic fatty acid synthase inhibitor, C45, is a nonspecific neuronal activator. Endocrinology 2004 PMID: 14512433
• Kuhajda Synthesis and antitumor activity of an inhibitor of fatty acid synthase. Proc.Natl.Acad.Sci.
• Zhou Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells. Cancer Res. 2003 PMID: 14612531

Product Documents for C 75