Chemical Name: (2R*,3S*)-Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylic acid
Biological ActivitySynthetic inhibitor of fatty acid synthase (FASN); inhibits fatty acid synthesis in vitro and in vivo. Displays anorectic effects. Induces apoptosis in MCF-7 xenografts and exhibits antitumor activity.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells.
Zhou et al.
Cancer Res., 2003;63:7330
The anorexigenic fatty acid synthase inhibitor, C45, is a nonspecific neuronal activator.
Takahashi et al.
Synthesis and antitumor activity of an inhibitor of fatty acid synthase.
Kuhajda et al.
Chronic C75 treatment of diet-induced obese mice increases fat oxidation and reduces food intake to reduce adipose mass.
Thupari et al.
Citation for C 75
The citations listed below are publications that use Tocris products. Selected citations for C 75 include:
1 Citation: Showing 1 - 1
The fatty acid synthase inhibitor triclosan: repurposing an anti-microbial agent for targeting prostate cancer.
Authors: Sadowski Et al.
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