C 75

Catalog # Availability Size / Price Qty
2489/10
2489/50
C 75 | CAS No. 191282-48-1 | Fatty Acid Synthase Inhibitors
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Description: Potent fatty acid synthase inhibitor; proapoptotic
Alternative Names: trans-C 75

Chemical Name: (2R*,3S*)-Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylic acid

Purity: ≥99%

Product Details
Citations (1)
Reviews

Biological Activity

Synthetic inhibitor of fatty acid synthase (FASN); inhibits fatty acid synthesis in vitro and in vivo. Displays anorectic effects. Induces apoptosis in MCF-7 xenografts and exhibits antitumor activity.

Technical Data

M.Wt:
254.32
Formula:
C14H22O4
Solubility:
Soluble to 100 mM in 1eq. NaOH and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
191282-48-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells.
    Zhou et al.
    Cancer Res., 2003;63:7330
  2. The anorexigenic fatty acid synthase inhibitor, C45, is a nonspecific neuronal activator.
    Takahashi et al.
    Endocrinology, 2004;145:184
  3. Synthesis and antitumor activity of an inhibitor of fatty acid synthase.
    Kuhajda et al.
    Proc.Natl.Acad.Sci., 2000;97:3450
  4. Chronic C75 treatment of diet-induced obese mice increases fat oxidation and reduces food intake to reduce adipose mass.
    Thupari et al.
    Am.J.Physiol.Endocrinol.Metab., 2004;287:97

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Citation for C 75

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