Catalog Number: 2489
Alternate Names: trans-C 75
Chemical Name: (2R*,3S*)-Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylic acid
Biological Activity
Synthetic inhibitor of fatty acid synthase (FASN); inhibits fatty acid synthesis in vitro and in vivo. Displays anorectic effects. Induces apoptosis in MCF-7 xenografts and exhibits anti-tumor activity.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in 1eq. NaOH and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells.
    Zhou et al.
    Cancer Res., 2003;63:7330
  2. The anorexigenic fatty acid synthase inhibitor, C45, is a nonspecific neuronal activator.
    Takahashi et al.
    Endocrinology, 2004;145:184
  3. Synthesis and antitumor activity of an inhibitor of fatty acid synthase.
    Kuhajda et al.
    Proc.Natl.Acad.Sci., 2000;97:3450
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