Synthetic inhibitor of fatty acid synthase (FASN); inhibits fatty acid synthesis in vitro
and in vivo
. Displays anorectic effects. Induces apoptosis in MCF-7 xenografts and exhibits anti-tumor activity.
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Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells.
Zhou et al.
Cancer Res., 2003;63:7330
The anorexigenic fatty acid synthase inhibitor, C45, is a nonspecific neuronal activator.
Takahashi et al.
Synthesis and antitumor activity of an inhibitor of fatty acid synthase.
Kuhajda et al.