Caerulein
Purity: ≥95%
Biological Activity
Caerulein is a CCK agonist. Stimulates biosynthesis of pancreatic enzymes in AR4-2J pancreatic cells in vitro. Induces acute pancreatitis in mice. Also enhances proteasome activity in Gdeg mice.Technical Data
(Modifications: X = Glp, Tyr-4 = Tyr(SO3H), Phe-10 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Yes-associated protein mediates immune reprogramming in pancreatic ductal adenocarcinoma.
Murakami et al.
Oncogene, 2017;36:1232 -
Proteasome activity is required for the initiation of precancerous pancreatic lesions.
Furuyama et al.
Sci.Rep., 2016;6:27044 -
Caerulein and gastrin(2-17 ds) regulate differently synthesis of secretory enzymes, mRNA levels and cell proliferation in pancreatic acinar cells (AR4-2J).
Pradel et al.
Biochem.J., 1993;290:219
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Dissolve in recommended solvent and 50microgram/ kg, intraperitoneally administered to mice for 5 times to induce acute pancreatitis.
