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Product Description
Caerulein is a CCK agonist. Stimulates biosynthesis of pancreatic enzymes in AR4-2J pancreatic cells in vitro. Induces acute pancreatitis in mice. Also enhances proteasome activity in Gdeg mice.
Product Specifications for Caerulein
Molecular Weight
1352.40
Formula
C58H73N13O21S2
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
17650-98-5
PubChem ID
16132921
InChI Key
YRALAIOMGQZKOW-UHFFFAOYSA-N
SMILES
CC(C(C(=O)NCC(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CCSC)C(=O)NC(CC(=O)O)C(=O)NC(CC3=CC=CC=C3)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)OS(=O)(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)N)NC(=O)C5CCC(=O)N5)O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
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Solubility
| Solubility | Soluble to 1mg/ml in water |
Calculators
Background References
References are publications that support the biological activity of the product. See our Citations tab to view 13 publications citing the usage of this product.
- Furuyama Proteasome activity is required for the initiation of precancerous pancreatic lesions. Sci.Rep. 2016 PMID: 27244456
- Pradel Caerulein and gastrin(2-17 ds) regulate differently synthesis of secretory enzymes, mRNA levels and cell proliferation in pancreatic acinar cells (AR4-2J). Biochem.J. 1993 PMID: 7679894
- Murakami Yes-associated protein mediates immune reprogramming in pancreatic ductal adenocarcinoma. Oncogene 2017 PMID: 27546622
Product Documents for Caerulein
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for Caerulein
For research use only
Citations for Caerulein
Customer Reviews for Caerulein (1)
5 out of 5
1 Customer Rating
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Species: MouseAssay Type: In VivoVerified Customer | Posted 01/04/2018Dissolve in recommended solvent and 50microgram/ kg, intraperitoneally administered to mice for 5 times to induce acute pancreatitis.
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