Biological ActivityCaerulein is a CCK agonist. Stimulates biosynthesis of pancreatic enzymes in AR4-2J pancreatic cells in vitro. Induces acute pancreatitis in mice. Also enhances proteasome activity in Gdeg mice.
(Modifications: X = Glp, Tyr-4 = Tyr(SO3H), Phe-10 = C-terminal amide)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Yes-associated protein mediates immune reprogramming in pancreatic ductal adenocarcinoma.
Murakami et al.
Proteasome activity is required for the initiation of precancerous pancreatic lesions.
Furuyama et al.
Caerulein and gastrin(2-17 ds) regulate differently synthesis of secretory enzymes, mRNA levels and cell proliferation in pancreatic acinar cells (AR4-2J).
Pradel et al.
Citations for Caerulein
The citations listed below are publications that use Tocris products. Selected citations for Caerulein include:
3 Citations: Showing 1 - 3
A microRNA checkpoint for Ca2+ signaling and overload in acute pancreatitis.
Authors: Xiaofeng Et al.
Mol Ther 2022;30:1754-1774
Parabacteroides produces acetate to alleviate heparanase-exacerbated acute pancreatitis through reducing neutrophil infiltration.
Authors: Li Et al.
TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation.
Authors: Stephen J Et al.
J Clin Invest 2020;130:2527-2541
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