Chemical Name: N-[3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]-O-phosphono-L-tyrosyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-glutamic acid
Biological ActivityPhosphopeptide ligand for the src SH2 domain (IC50 = 42 nM); displays 30-fold higher affinity than N-acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu (Ac-pYEEIE, Cat. No. 1927).
(Modifications: Tyr-1 = N-[3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]-)-pTyr, Glu-2 = αGlu, Glu-3 = αGlu)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Design and characterization of non-phosphopeptide inhibitors for src family SH2 domains.
Park et al.
Citation for Caffeic acid-pYEEIE
The citations listed below are publications that use Tocris products. Selected citations for Caffeic acid-pYEEIE include:
1 Citation: Showing 1 - 1
A selective NMR probe to monitor the conformational transition from inactive to active kinase.
Authors: Xie Et al.
J Neurosci 2015;10:262
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