Catalog Number: 1935
Chemical Name: N-[3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]-O-phosphono-L-tyrosyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-glutamic acid
Biological Activity
Phosphopeptide ligand for the src SH2 domain (IC50 = 42 nM); displays 30-fold higher affinity than N-acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu (Ac-pYEEIE, Cat. No. 1927).
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Tyr-1 = N-[3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]-)-pTyr, Glu-2 = αGlu, Glu-3 = αGlu)

  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Design and characterization of non-phosphopeptide inhibitors for src family SH2 domains.
    Park et al.
    Bioorg.Med.Chem.Lett., 2002;12:2711

The citations listed below are publications that use Tocris products. Selected citations for Caffeic acid-pYEEIE include:

Showing Results 1 - 1 of 1

  1. A selective NMR probe to monitor the conformational transition from inactive to active kinase.
    Authors: Xie Et al.
    J Neurosci
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