Chemical Name: 3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
Biological ActivityCaffeine is a central nervous system stimulant. Antagonist at A1 and A2A adenosine receptors and inhibitor of cyclic nucleotide phosphodiesterases. Mobilizes calcium from intracellular stores and inhibits benzodiazepine binding to GABA receptors.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects.
Nehlig et al.
Brain Res.Brain Res.Rev., 1992;17:139
Caffeine as a psychomotor stimulant: mechanism of action.
Fisone et al.
Cell.Mol.Life Sci., 2004;61:857
Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease.
Chen et al.
Citations for Caffeine
The citations listed below are publications that use Tocris products. Selected citations for Caffeine include:
2 Citations: Showing 1 - 2
Contrasting Effects of the Cytotoxic Anticancer Drug gemcit. and the EGFR Tyrosine Kinase Inhibitor gefi. on NK Cell-Mediated Cytotoxicity via Regulation of NKG2D Ligand in Non-Small-Cell Lung Cancer Cells.
Authors: Okita Et al.
PLoS One 2015;10:e0139809
Acute SimV. inhibits K ATP channels of porcine coronary artery myocytes.
Authors: Seto Et al.
J Cell Sci 2013;8:e66404
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