Catalog Number: 2793
Chemical Name: 3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
Biological Activity
Central nervous system stimulant. Antagonist at A1 and A2A adenosine receptors and inhibitor of cyclic nucleotide phosphodiesterases. Mobilizes calcium from intracellular stores and inhibits benzodiazepine binding to GABA receptors.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 50 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects.
    Nehlig et al.
    Brain Res.Brain Res.Rev., 1992;17:139
  2. Caffeine as a psychomotor stimulant: mechanism of action.
    Fisone et al.
    Cell.Mol.Life Sci., 2004;61:857
  3. Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease.
    Chen et al.
    J.Neuroinflammation, 2008;5:12

The citations listed below are publications that use Tocris products. Selected citations for Caffeine include:

Showing Results 1 - 2 of 2

  1. Contrasting Effects of the Cytotoxic Anticancer Drug Gemcitabine and the EGFR Tyrosine Kinase Inhibitor Gefitinib on NK Cell-Mediated Cytotoxicity via Regulation of NKG2D Ligand in Non-Small-Cell Lung Cancer Cells.
    Authors: Okita Et al.
    PLoS One
  2. Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes.
    Authors: Seto Et al.
    J Cell Sci
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