Calcifediol
Chemical Name: (εR,1R,3aS,4E,7aR)-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]octahydro-α,α,ε,7a-tetramethyl-1H-indene-1-pentanol
Purity: ≥98%
Biological Activity
Calcifediol is a prohormone of calcitriol (Cat. No. 2551). Major circulating form of vitamin D. Suppresses PTH synthesis and secretion in bovine parathyroid cells (ED50 = 2 nM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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25-hydroxyvitamin D3 suppresses PTH synthesis and secretion by bovine parathyroid cells.
Ritter et al.
Kidney Int., 2006;70:654 -
Megalin-mediated endocytosis of vitamin D binding protein correlates with 25-hydroxycholecalciferol actions in human mammary cells.
Rowling et al.
J.Nutr., 2006;136:2754 -
Blood 25-hydroxyvitamin D3 concentrations and incident sporadic colorectal adenoma risk: a pooled case-control study.
Fedirko et al.
Am.J.Epidemiol., 2010;172:489
Product Datasheets
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Citation for Calcifediol
The citations listed below are publications that use Tocris products. Selected citations for Calcifediol include:
1 Citation: Showing 1 - 1
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Vitamin D Inhibits Expression and Activity of Matrix Metalloproteinase in Human Lung Fibroblasts (HFL-1) Cells.
Authors: Kim Et al.
Biochim Biophys Acta 2014;77:73
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