Calhex 231 hydrochloride

Key Product Details

Product Description

Calhex 231 hydrochloride is a negative allosteric modulator of the calcium sensing receptor (CaSR). Blocks increases in [³H]inositol phosphate levels elicited by wild-type hCasR activation (IC₅₀= 0.39 μM in transiently transfected HEK293 cells).

Product Specifications for Calhex 231 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Calhex 231 hydrochloride

The following data is based on the product molecular weight 443.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.51 mL	22.55 mL	45.10 mL
2.5 mM	0.90 mL	4.51 mL	9.02 mL
5 mM	0.45 mL	2.26 mL	4.51 mL
25 mM	0.09 mL	0.45 mL	0.90 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Kessler N1-Benzoyl-N2-[1-(1-naphthyl)ethyl]-trans-1,2-diaminocyclohexanes: Development of 4-chlorophenylcarboxamide (Calhex 231) as a new calcium sensing receptor ligand demonstrating potent calcilytic activity. J.Med.Chem. 2006 PMID: 16913701
• Weston The expression and function of Ca²⁺-sensing receptors in rat mesenteric artery; comparative studies using a model of type II diabetes. Br.J.Pharmacol. 2008 PMID: 18414396
• Petrel Modeling and mutagenesis of the binding site of Calhex 231, a novel negative allosteric modulator of the extracellular Ca²⁺-sensing receptor. J.Biol.Chem. 2003 PMID: 14506236

Product Documents for Calhex 231 hydrochloride