Negative allosteric modulator of the calcium sensing receptor (CaSR). Blocks increases in [3
H]inositol phosphate levels elicited by wild-type hCasR activation (IC50
= 0.39 μ
M in transiently transfected HEK293 cells).
Soluble to 50 mM in DMSO
Store at -20°C
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Modeling and mutagenesis of the binding site of Calhex 231, a novel negative allosteric modulator of the extracellular Ca2+-sensing receptor.
Petrel et al.
N1-Benzoyl-N2-[1-(1-naphthyl)ethyl]-trans-1,2-diaminocyclohexanes: Development of 4-chlorophenylcarboxamide (Calhex 231) as a new calcium sensing receptor ligand demonstrating potent calcilytic activity.
Kessler et al.
The expression and function of Ca2+-sensing receptors in rat mesenteric artery; comparative studies using a model of type II diabetes.
Weston et al.
The citations listed below are publications that use Tocris products. Selected citations for Calhex 231 hydrochloride include:
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