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Calhex 231 hydrochloride

  ( 2 citations )    
Product Datasheet
Catalog Number:4387
Chemical Name:4-Chloro-N-[(1S,2S)-2-[[(1R)-1-(1-naphthalenyl)ethyl]amino]cyclohexyl]-benzamide hydrochloride
Product Details
Citations (2)
Supplemental Products
Reviews
Biological Activity
Negative allosteric modulator of the calcium sensing receptor (CaSR). Blocks increases in [3H]inositol phosphate levels elicited by wild-type hCasR activation (IC50= 0.39 μM in transiently transfected HEK293 cells).
Technical Data
  • M.Wt:
    443.41
  • Formula:
    C25H27ClN2O.HCl
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    652973-93-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Calhex 231 hydrochloride include:

2 Citations: Showing 1 - 2
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  1. Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma.
    Authors: Yarova Et al.
    Diabetologia  2015;7:284ra60
  2. Oligopeptides stimulate glucagon-like peptide-1 secretion in mice through proton-coupled uptake and the calcium-sensing receptor.
    Authors: Diakogiannaki Et al.
    Oncotarget  2013;56:2688

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