Negative allosteric modulator of the calcium sensing receptor (CaSR). Blocks increases in [
H]inositol phosphate levels elicited by wild-type hCasR activation (IC
M in transiently transfected HEK293 cells).
25H 27ClN 2O.HCl
Soluble to 50 mM in DMSO
Store at -20°C
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All Tocris products are intended for laboratory research use only.
Modeling and mutagenesis of the binding site of Calhex 231, a novel negative allosteric modulator of the extracellular Ca 2+-sensing receptor.
Petrel et al.
N 1-Benzoyl- N 2-[1-(1-naphthyl)ethyl]- trans-1,2-diaminocyclohexanes: Development of 4-chlorophenylcarboxamide (Calhex 231) as a new calcium sensing receptor ligand demonstrating potent calcilytic activity.
Kessler et al.
The expression and function of Ca 2+-sensing receptors in rat mesenteric artery; comparative studies using a model of type II diabetes.
Weston et al.
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