Catalog Number: 4387
Chemical Name: 4-Chloro-N-[(1S,2S)-2-[[(1R)-1-(1-naphthalenyl)ethyl]amino]cyclohexyl]-benzamide hydrochloride
Biological Activity
Negative allosteric modulator of the calcium sensing receptor (CaSR). Blocks increases in [3H]inositol phosphate levels elicited by wild-type hCasR activation (IC50= 0.39 μM in transiently transfected HEK293 cells).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Modeling and mutagenesis of the binding site of Calhex 231, a novel negative allosteric modulator of the extracellular Ca2+-sensing receptor.
    Petrel et al.
    J.Biol.Chem., 2003;278:49487
  2. N1-Benzoyl-N2-[1-(1-naphthyl)ethyl]-trans-1,2-diaminocyclohexanes: Development of 4-chlorophenylcarboxamide (Calhex 231) as a new calcium sensing receptor ligand demonstrating potent calcilytic activity.
    Kessler et al.
    J.Med.Chem., 2006;49:5119
  3. The expression and function of Ca2+-sensing receptors in rat mesenteric artery; comparative studies using a model of type II diabetes.
    Weston et al.
    Br.J.Pharmacol., 2008;154:652

The citations listed below are publications that use Tocris products. Selected citations for Calhex 231 hydrochloride include:

Showing Results 1 - 2 of 2

  1. Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma.
    Authors: Yarova Et al.
  2. Oligopeptides stimulate glucagon-like peptide-1 secretion in mice through proton-coupled uptake and the calcium-sensing receptor.
    Authors: Diakogiannaki Et al.
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