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CALP1

  ( 2 citations )    
Product Datasheet
Catalog Number:2090
Alternate Names:Calcium-like peptide 1
Chemical Name:
Product Details
Citations (2)
Reviews
Biological Activity
Cell-permeable calmodulin (CaM) agonist that binds to the EF-hand/Ca2+-binding site; produces CaM-dependent activation of phosphodiesterase. Also binds to cytoplasmic sites on other Ca2+ channels, including NMDA and HIV-1 gp120-activated channels, inhibiting Ca2+-mediated cytotoxicity and apoptosis (IC50 = 52 μM). Shown to protect pancreatic acinar cells from gossypol (Cat.No. 1964) induced necrosis. Inhibits VLA-5-mediated adhesion of mast cells to fibronectin in vitro and attenuates inflammatory cell influx in guinea pig lung in vivo.
Technical Data
  • M.Wt:
    842.09
  • Formula:
    C40H75N9O10
  • Sequence:
    VAITVLVK
  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    145224-99-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for CALP1 include:

2 Citations: Showing 1 - 2
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  1. BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides.
    Authors: Ferdek Et al.
    Cell.Death.Dis.  2017;8
  2. The Ca(v)3.1 T-type calcium channel is required for neointimal formation in response to vascular injury in mice.
    Authors: Tzeng Et al.
    Cardiovasc Res  2012;96:533

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