CALP1

Key Product Details

Product Description

CALP1 is a cell-permeable calmodulin (CaM) agonist that binds to the EF-hand/Ca²⁺-binding site; produces CaM-dependent activation of phosphodiesterase. Also binds to cytoplasmic sites on other Ca²⁺ channels, including NMDA and HIV-1 gp120-activated channels, inhibiting Ca²⁺-mediated cytotoxicity and apoptosis (IC₅₀ = 52 μM). Shown to protect pancreatic acinar cells from gossypol (Cat.No. 1964) induced necrosis. Inhibits VLA-5-mediated adhesion of mast cells to fibronectin in vitro and attenuates inflammatory cell influx in guinea pig lung in vivo.

Product Specifications for CALP1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 15 publications citing the usage of this product.

• Ferdek BH3 mimetic-elicited Ca²⁺ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca²⁺-like peptides. Cell.Death.Dis. 2017 PMID: 28252652
• Villain De novo design of peptides targeted to the EF hands of calmodulin. J.Biol.Chem.
• Houtman Attenuation of very late antigen-5-mediated adhesion of bone marrow-derived mast cells to fibronectin by peptides with inverted hydropathy to EF-hands. J.Immunol. 2001 PMID: 11145661
• Ten Broeke Ca²⁺ sensors modulate asthmatic symptoms in an allergic model for asthma. Eur.J.Pharmacol. 2003 PMID: 12969760
• Manion A new type of Ca²⁺ channel blocker that targets Ca²⁺ sensors and prevents Ca²⁺-mediated apoptosis. FASEB J. 2000 PMID: 10877822

Product Documents for CALP1