CALP1

Biological Activity

CALP1 is a cell-permeable calmodulin (CaM) agonist that binds to the EF-hand/Ca²⁺-binding site; produces CaM-dependent activation of phosphodiesterase. Also binds to cytoplasmic sites on other Ca²⁺ channels, including NMDA and HIV-1 gp120-activated channels, inhibiting Ca²⁺-mediated cytotoxicity and apoptosis (IC₅₀ = 52 μM). Shown to protect pancreatic acinar cells from gossypol (Cat.No. 1964) induced necrosis. Inhibits VLA-5-mediated adhesion of mast cells to fibronectin in vitro and attenuates inflammatory cell influx in guinea pig lung in vivo.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. BH3 mimetic-elicited Ca²⁺ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca²⁺-like peptides.
   Ferdek et al.
   Cell.Death.Dis., 2017;8
2. A new type of Ca²⁺ channel blocker that targets Ca²⁺ sensors and prevents Ca²⁺-mediated apoptosis.
   Manion et al.
   FASEB J., 2000;14:1297
3. Attenuation of very late antigen-5-mediated adhesion of bone marrow-derived mast cells to fibronectin by peptides with inverted hydropathy to EF-hands.
   Houtman et al.
   J.Immunol., 2001;166:861
4. Ca²⁺ sensors modulate asthmatic symptoms in an allergic model for asthma.
   Ten Broeke et al.
   Eur.J.Pharmacol., 2003;476:151
5. De novo design of peptides targeted to the EF hands of calmodulin.
   Villain et al.
   J.Biol.Chem., 2000;274:2676

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