Cell-permeable calmodulin (CaM) agonist that binds to the EF-hand/Ca2+
-binding site; produces CaM-dependent activation of phosphodiesterase. Also binds to cytoplasmic sites on other Ca2+
channels, including NMDA� and HIV-1 gp120-activated channels, inhibiting Ca2+
-mediated cytotoxicity and apoptosis (IC50
= 52 μ
M). Inhibits VLA-5-mediated adhesion of mast cells to fibronectin in vitro
and attenuates inflammatory cell influx in guinea pig lung in vivo
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All Tocris products are intended for laboratory research use only.
A new type of Ca2+ channel blocker that targets Ca2+ sensors and prevents Ca2+-mediated apoptosis.
Manion et al.
FASEB J., 2000;14:1297
Attenuation of very late antigen-5-mediated adhesion of bone marrow-derived mast cells to fibronectin by peptides with inverted hydropathy to EF-hands.
Houtman et al.
Ca2+ sensors modulate asthmatic symptoms in an allergic model for asthma.
Ten Broeke et al.
De novo design of peptides targeted to the EF hands of calmodulin.
Villain et al.
The citations listed below are publications that use Tocris products. Selected citations for CALP1 include:
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