Catalog Number: 2090
Alternate Names: Calcium-like peptide 1
Biological Activity
Cell-permeable calmodulin (CaM) agonist that binds to the EF-hand/Ca2+-binding site; produces CaM-dependent activation of phosphodiesterase. Also binds to cytoplasmic sites on other Ca2+ channels, including NMDA� and HIV-1 gp120-activated channels, inhibiting Ca2+-mediated cytotoxicity and apoptosis (IC50 = 52 μM). Shown to protect pancreatic acinar cells from gossypol (Cat.No. 1964) induced necrosis. Inhibits VLA-5-mediated adhesion of mast cells to fibronectin in vitro and attenuates inflammatory cell influx in guinea pig lung in vivo.
Technical Data
  • M.Wt:
    842.09
  • Formula:
    C40H75N9O10
  • Sequence:
    VAITVLVK
  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    145224-99-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A new type of Ca2+ channel blocker that targets Ca2+ sensors and prevents Ca2+-mediated apoptosis.
    Manion et al.
    FASEB J., 2000;14:1297
  2. Attenuation of very late antigen-5-mediated adhesion of bone marrow-derived mast cells to fibronectin by peptides with inverted hydropathy to EF-hands.
    Houtman et al.
    J.Immunol., 2001;166:861
  3. Ca2+ sensors modulate asthmatic symptoms in an allergic model for asthma.
    Ten Broeke et al.
    Eur.J.Pharmacol., 2003;476:151
  4. De novo design of peptides targeted to the EF hands of calmodulin.
    Villain et al.
    J.Biol.Chem., 2000;274:2676
  5. BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides.
    Ferdek et al.
    Cell.Death.Dis., 2017;8
Citations:

The citations listed below are publications that use Tocris products. Selected citations for CALP1 include:

2 Citations: Showing 1 - 2
Filter your results:

  1. BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides.
    Authors: Ferdek Et al.
    Cell.Death.Dis. 2017;8
  2. The Ca(v)3.1 T-type calcium channel is required for neointimal formation in response to vascular injury in mice.
    Authors: Tzeng Et al.
    Cardiovasc Res 2012;96:533

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