Catalog Number: 1626
Alternate Names: UCN 1028C, PKF 115584
Chemical Name: (1R)-2-[12-[(2R)-2-(Benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethylcarbonic acid 4-hydroxyphenyl ester
Biological Activity
Potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain (IC50 = 50 nM). Displays > 1000-fold selectivity over other protein kinases such as cAMP-dependent protein kinase and tyrosine-specific protein kinase. Inhibits cell proliferation of malignant glioma cells in light-treated conditions in vitro (IC50 ~ 40 - 60 nM). Also an antagonist of the Tcf/β-catenin complex.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble in DMSO and in ethanol
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The effect of calphostin C, a potent photodependent protein kinase C inhibitor, on the proliferation of glioma cells in vitro.
    Pollack and Kawecki
    J.Neurooncol., 1997;31:255
  2. Differential effects of photofrin, 5-aminolevulinic acid and calphostin C on glioma cells.
    Au et al.
    J.Photochem.Photobiol.B., 2006;85:92
  3. In vitro effects of a small-molecule antagonist of the Tcf/β-catenin complex on endometrial and endometriotic cells of patients with endometriosis.
    Matsuzaki and Darcha
    PLoS One, 2013;8:e61690
  4. Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C.
    Kobayashi et al.
    Biochem.Biophys.Res.Comm., 1989;159:548
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