Calphostin C

  ( 5 citations )    
Product Datasheet
Catalog Number:1626
Alternate Names:UCN 1028C, PKF 115584
Chemical Name:(1R)-2-[12-[(2R)-2-(Benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethylcarbonic acid 4-hydroxyphenyl ester
Product Details
Citations (5)
Reviews
Biological Activity
Potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain (IC50 = 50 nM). Displays > 1000-fold selectivity over other protein kinases such as cAMP-dependent protein kinase and tyrosine-specific protein kinase. Inhibits cell proliferation of malignant glioma cells in light-treated conditions in vitro (IC50 ~ 40 - 60 nM). Also an antagonist of the Tcf/β-catenin complex.
Technical Data
  • M.Wt:
    790.76
  • Formula:
    C44H38O14
  • Solubility:
    Soluble in DMSO and in ethanol
  • Purity:
    >98
  • Storage:
    Desiccate at +4°C
  • CAS No:
    121263-19-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Calphostin C include:

5 Citations: Showing 1 - 5
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  1. A novel mechanism for cytoprotection against hypoxic injury: δ-opioid receptor-mediated increase in Nrf2 translocation.
    Authors: Cao Et al.
    PLoS One  2015;172:1869
  2. Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol.
    Authors: Merino Et al.
    Am J Physiol Regul Integr Comp Physiol  2015;10:e0132884
  3. δ-Opioid receptors up-regulate excitatory amino acid transporters in mouse astrocytes.
    Authors: Liang Et al.
    Br J Pharmacol  2014;171:5417
  4. S100A1 deficiency impairs postischemic angiogenesis via compromised proangiogenic endothelial cell function and nitric oxide synthase regulation.
    Authors: Most Et al.
    Circ Res  2013;112:66
  5. Killing of cancer cells by the photoactivatable protein kinase C inhibitor, calphostin C, involves induction of endoplasmic reticulum stress.
    Authors: Kaul and Maltese
    Neoplasia  2009;11:823

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