Catalog Number: 1626
Alternate Names: UCN 1028C, PKF 115584
Chemical Name: (1R)-2-[12-[(2R)-2-(Benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethylcarbonic acid 4-hydroxyphenyl ester
Biological Activity
Potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain (IC50 = 50 nM). Displays > 1000-fold selectivity over other protein kinases such as cAMP-dependent protein kinase and tyrosine-specific protein kinase. Inhibits cell proliferation of malignant glioma cells in light-treated conditions in vitro (IC50 ~ 40 - 60 nM). Also an antagonist of the Tcf/β-catenin complex.
Technical Data
  • M.Wt:
    790.76
  • Formula:
    C44H38O14
  • Solubility:
    Soluble in DMSO and in ethanol
  • Purity:
    >98%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    121263-19-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The effect of calphostin C, a potent photodependent protein kinase C inhibitor, on the proliferation of glioma cells in vitro.
    Pollack and Kawecki
    J.Neurooncol., 1997;31:255
  2. Differential effects of photofrin, 5-aminolevulinic acid and calphostin C on glioma cells.
    Au et al.
    J.Photochem.Photobiol.B., 2006;85:92
  3. In vitro effects of a small-molecule antagonist of the Tcf/β-catenin complex on endometrial and endometriotic cells of patients with endometriosis.
    Matsuzaki and Darcha
    PLoS One, 2013;8:e61690
  4. Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C.
    Kobayashi et al.
    Biochem.Biophys.Res.Comm., 1989;159:548
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Calphostin C include:

4 Citations: Showing 1 - 4
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  1. A novel mechanism for cytoprotection against hypoxic injury: δ-opioid receptor-mediated increase in Nrf2 translocation.
    Authors: Cao Et al.
    PLoS One 2015;172:1869
  2. Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol.
    Authors: Merino Et al.
    Am J Physiol Regul Integr Comp Physiol 2015;10:e0132884
  3. δ-Opioid receptors up-regulate excitatory amino acid transporters in mouse astrocytes.
    Authors: Liang Et al.
    Br J Pharmacol 2014;171:5417
  4. S100A1 deficiency impairs postischemic angiogenesis via compromised proangiogenic endothelial cell function and nitric oxide synthase regulation.
    Authors: Most Et al.
    Circ Res 2013;112:66

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