Potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain (IC50
= 50 nM). Displays > 1000-fold selectivity over other protein kinases such as cAMP-dependent protein kinase and tyrosine-specific protein kinase. Inhibits cell proliferation of malignant glioma cells in light-treated conditions in vitro
~ 40 - 60 nM). Also an antagonist of the Tcf/β
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The effect of calphostin C, a potent photodependent protein kinase C inhibitor, on the proliferation of glioma cells in vitro.
Pollack and Kawecki
Differential effects of photofrin, 5-aminolevulinic acid and calphostin C on glioma cells.
Au et al.
In vitro effects of a small-molecule antagonist of the Tcf/β-catenin complex on endometrial and endometriotic cells of patients with endometriosis.
Matsuzaki and Darcha
PLoS One, 2013;8:e61690
Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C.
Kobayashi et al.
The citations listed below are publications that use Tocris products. Selected citations for Calphostin C include:
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