cAMPS-Rp, triethylammonium salt

  ( 11 citations )    
Product Datasheet
Catalog Number:1337
Chemical Name:(R)-Adenosine, cyclic 3',5'-(hydrogenphosphorothioate) triethylammonium
Product Details
Citations (11)
Reviews
Biological Activity
Cell-permeable cAMP analog; acts as a competitive antagonist of cAMP-induced activation of PKA (IC50 = 11 - 16 μM) by interacting with cAMP binding sites on the regulatory subunits. Resistant to hydrolysis by phosphodiesterases.

S-enantiomer also available.

Technical Data
  • M.Wt:
    446.46
  • Formula:
    C10H12N5O5PS.C6H15N
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >98
  • Storage:
    Desiccate at -20°C
  • CAS No:
    151837-09-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for cAMPS-Rp, triethylammonium salt include:

11 Citations: Showing 1 - 10
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  1. cAMP-dependent cell differentiation triggered by activated CRHR1 in hippocampal neuronal cells.
    Authors: Inda Et al.
    Sci Rep  2017;7:1944
  2. GLP-1 acts on habenular avoidance circuits to control nicotine intake.
    Authors: Tuesta
    Nat Neurosci  2017;20(5):708
  3. Different cAMP sources are critically involved in G protein-coupled receptor CRHR1 signaling.
    Authors: Inda Et al.
    J Cell Biol  2016;214:181
  4. Endogenous 17β-estradiol is required for activity-dependent long-term potentiation in the striatum: interaction with the dopaminergic system.
    Authors: Tozzi Et al.
    Front Cell Neurosci  2015;9:192
  5. Thiopental inhibits global protein synthesis by repression of eukaryotic elongation factor 2 and protects from hypoxic neuronal cell death.
    Authors: Schwer Et al.
    PLoS One  2013;8:e77258
  6. Pituitary adenylate cyclase-activating polypeptide induces postsynaptically expressed potentiation in the intra-amygdala circuit.
    Authors: Cho Et al.
    J Neurosci  2012;32:14165
  7. Astrocyte-derived thrombospondins mediate the development of hippocampal presynaptic plasticity in vitro.
    Authors: Crawford Et al.
    Biochem Biophys Res Commun  2012;32:13100
  8. Adenylate cyclase 5 coordinates the action of ADP, P2Y1, P2Y13 and ATP-gated P2X7 receptors on axonal elongation.
    Authors: Puerto Et al.
    J Cell Sci  2012;125:176
  9. Lateral paracapsular GABAergic synapses in the basolateral amygdala contribute to the anxiolytic effects of beta 3 adrenoceptor activation.
    Authors: Silberman Et al.
    Neuropsychopharmacology  2010;35:1886
  10. Amphetamine modulation of long-term potentiation in the prefrontal cortex: dose dependency, monoaminergic contributions, and paradoxical rescue in hyperdopaminergic mutant.
    Authors: Xu Et al.
    Endocrinology  2010;115:1643
  11. Melanocortinergic modulation of cholecystokinin-induced suppression of feeding through extracellular signal-regulated kinase signaling in rat solitary nucleus.
    Authors: Sutton Et al.
    J Neurosci  2005;146:3739
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