Cell-permeable cAMP analog; acts as a competitive antagonist of cAMP-induced activation of PKA (IC50
= 11 - 16 μ
M) by interacting with cAMP binding sites on the regulatory subunits. Resistant to hydrolysis by phosphodiesterases. Enantiomer cAMPS-Sp, triethylammonium salt
(Cat. No. 1333) also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
PKA and ERK, but not PKC, in the amygdala contribute to pain-related synaptic plasticity and behavior.
Fu et al.
Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates.
Dostmann et al.
Isoproterenol inhibits rod outer segment phagocytosis by both cAMP-dependent and independent pathways.
Kuriyama et al.
A mechanistic and kinetic analysis of the interactions of the diastereoisomers of adenosine 3',5'-(cyclic)phosphorothioate with purified cyclic AMP-dependent protein kinase.
Rothermel and Botelho
Competitive cAMP antagonists for cAMP-receptor proteins.
Van Haastert et al.
Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats.
Duca et al.
The citations listed below are publications that use Tocris products. Selected citations for cAMPS-Rp, triethylammonium salt include:
Showing Results 1 - 8 of 8