cAMPS-Rp, triethylammonium salt
Tocris Bioscience | Catalog # 1337
Product Description
cAMPS-Rp, triethylammonium salt is a cell-permeable cAMP analog; acts as a competitive antagonist of cAMP-induced activation of PKA (IC50 = 11 - 16 μM) by interacting with cAMP binding sites on the regulatory subunits. Resistant to hydrolysis by phosphodiesterases.
Product Specifications for cAMPS-Rp, triethylammonium salt
Molecular Weight
Formula
Storage
Purity
Chemical Name
CAS Number
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SMILES
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 44.65 | 100 |
Preparing Stock Solutions for cAMPS-Rp, triethylammonium salt
The following data is based on the product molecular weight 446.46.
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.24 mL | 11.20 mL | 22.40 mL |
| 5 mM | 0.45 mL | 2.24 mL | 4.48 mL |
| 10 mM | 0.22 mL | 1.12 mL | 2.24 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.45 mL |
Calculators
Background References
References are publications that support the biological activity of the product. See our Citations tab to view 36 publications citing the usage of this product.
- Duca MetF. activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats. Nat.Med. 2015 PMID: 25849133
- Van Haastert Competitive cAMP antagonists for cAMP-receptor proteins. J.Biol.Chem. 1984 PMID: 6088478
- Rothermel and Botelho A mechanistic and kinetic analysis of the interactions of the diastereoisomers of adenosine 3',5'-(cyclic)phosphorothioate with purified cyclic AMP-dependent protein kinase. Biochem.J. 1988 PMID: 2843164
- Kuriyama Isoproterenol inhibits rod outer segment phagocytosis by both cAMP-dependent and independent pathways. Invest.Ophthalmol.Vis.Sci. 1995 PMID: 7890503
- Fu PKA and ERK, but not PKC, in the amygdala contribute to pain-related synaptic plasticity and behavior. Mol.Pain 2008 PMID: 18631385
- Dostmann Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates. J.Biol.Chem. 1990 PMID: 2162349
Product Documents for cAMPS-Rp, triethylammonium salt
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for cAMPS-Rp, triethylammonium salt
For research use only
Citations for cAMPS-Rp, triethylammonium salt
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Species: HumanAssay Type: In VitroVerified Customer | Posted 12/26/2023Pancreatic cancer cells were pretreated for 2 hours with cAMPS-Rp, triethylammonium salt followed by conventional chemotherapeutics. Impairment of cAMP-induced activation of PKA mediated the biological effects of chemotherapeutics.
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