cAMPS-Rp, triethylammonium salt

Catalog # Availability Size / Price Qty
1337/1
cAMPS-Rp, triethylammonium salt | CAS No. 151837-09-1 | cAMP Compounds
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Description: cAMP antagonist

Chemical Name: (R)-Adenosine, cyclic 3',5'-(hydrogenphosphorothioate) triethylammonium

Purity: ≥98%

Product Details
Citations (13)
Reviews

Biological Activity

Cell-permeable cAMP analog; acts as a competitive antagonist of cAMP-induced activation of PKA (IC50 = 11 - 16 μM) by interacting with cAMP binding sites on the regulatory subunits. Resistant to hydrolysis by phosphodiesterases.

Technical Data

M.Wt:
446.46
Formula:
C10H12N5O5PS.C6H15N
Solubility:
Soluble to 100 mM in water
Purity:
≥98%
Storage:
Desiccate at -20°C
CAS No:
151837-09-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for cAMPS-Rp, triethylammonium salt

The citations listed below are publications that use Tocris products. Selected citations for cAMPS-Rp, triethylammonium salt include:

13 Citations: Showing 1 - 10

  1. Trio Haploinsufficiency Causes Neurodevelopmental Disease-Associated Deficits.
    Authors: Katrancha Et al.
    Cell Rep  2019;26:2805
  2. Enriched environment enhances β-adrenergic signaling to prevent microglia inflammation by amyloid-β.
    Authors: Xu Et al.
    EMBO Mol Med  2018;10
  3. cAMP-dependent cell differentiation triggered by activated CRHR1 in hippocampal neuronal cells.
    Authors: Inda Et al.
    Sci Rep  2017;7:1944
  4. GLP-1 acts on habenular avoidance circuits to control nicotine intake.
    Authors: Tuesta
    Nat Neurosci  2017;20(5):708
  5. Different cAMP sources are critically involved in G protein-coupled receptor CRHR1 signaling.
    Authors: Inda Et al.
    J Cell Biol  2016;214:181
  6. Endogenous 17β-OE is required for activity-dependent long-term potentiation in the striatum: interaction with the DArgic system.
    Authors: Tozzi Et al.
    Front Cell Neurosci  2015;9:192
  7. Thiopental inhibits global protein synthesis by repression of eukaryotic elongation factor 2 and protects from hypoxic neuronal cell death.
    Authors: Schwer Et al.
    PLoS One  2013;8:e77258
  8. Pituitary adenylate cyclase-activating polypeptide induces postsynaptically expressed potentiation in the intra-amygdala circuit.
    Authors: Cho Et al.
    J Neurosci  2012;32:14165
  9. Astrocyte-derived thrombospondins mediate the development of hippocampal presynaptic plasticity in vitro.
    Authors: Crawford Et al.
    Biochem Biophys Res Commun  2012;32:13100
  10. Adenylate cyclase 5 coordinates the action of ADP, P2Y1, P2Y13 and ATP-gated P2X7 receptors on axonal elongation.
    Authors: Puerto Et al.
    J Cell Sci  2012;125:176

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