cAMPS-Rp, triethylammonium salt
Chemical Name: (R)-Adenosine, cyclic 3',5'-(hydrogenphosphorothioate) triethylammonium
Biological ActivityCell-permeable cAMP analog; acts as a competitive antagonist of cAMP-induced activation of PKA (IC50 = 11 - 16 μM) by interacting with cAMP binding sites on the regulatory subunits. Resistant to hydrolysis by phosphodiesterases.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
MetF. activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats.
Duca et al.
PKA and ERK, but not PKC, in the amygdala contribute to pain-related synaptic plasticity and behavior.
Fu et al.
Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates.
Dostmann et al.
Isoproterenol inhibits rod outer segment phagocytosis by both cAMP-dependent and independent pathways.
Kuriyama et al.
A mechanistic and kinetic analysis of the interactions of the diastereoisomers of adenosine 3',5'-(cyclic)phosphorothioate with purified cyclic AMP-dependent protein kinase.
Rothermel and Botelho
Competitive cAMP antagonists for cAMP-receptor proteins.
Van Haastert et al.
Citations for cAMPS-Rp, triethylammonium salt
The citations listed below are publications that use Tocris products. Selected citations for cAMPS-Rp, triethylammonium salt include:
13 Citations: Showing 1 - 10
Trio Haploinsufficiency Causes Neurodevelopmental Disease-Associated Deficits.
Authors: Katrancha Et al.
Cell Rep 2019;26:2805
Enriched environment enhances β-adrenergic signaling to prevent microglia inflammation by amyloid-β.
Authors: Xu Et al.
EMBO Mol Med 2018;10
cAMP-dependent cell differentiation triggered by activated CRHR1 in hippocampal neuronal cells.
Authors: Inda Et al.
Sci Rep 2017;7:1944
GLP-1 acts on habenular avoidance circuits to control nicotine intake.
Nat Neurosci 2017;20(5):708
Different cAMP sources are critically involved in G protein-coupled receptor CRHR1 signaling.
Authors: Inda Et al.
J Cell Biol 2016;214:181
Endogenous 17β-OE is required for activity-dependent long-term potentiation in the striatum: interaction with the DArgic system.
Authors: Tozzi Et al.
Front Cell Neurosci 2015;9:192
Thiopental inhibits global protein synthesis by repression of eukaryotic elongation factor 2 and protects from hypoxic neuronal cell death.
Authors: Schwer Et al.
PLoS One 2013;8:e77258
Pituitary adenylate cyclase-activating polypeptide induces postsynaptically expressed potentiation in the intra-amygdala circuit.
Authors: Cho Et al.
J Neurosci 2012;32:14165
Astrocyte-derived thrombospondins mediate the development of hippocampal presynaptic plasticity in vitro.
Authors: Crawford Et al.
Biochem Biophys Res Commun 2012;32:13100
Adenylate cyclase 5 coordinates the action of ADP, P2Y1, P2Y13 and ATP-gated P2X7 receptors on axonal elongation.
Authors: Puerto Et al.
J Cell Sci 2012;125:176
Lateral paracapsular GABAergic synapses in the basolateral amygdala contribute to the anxiolytic effects of beta 3 adrenoceptor activation.
Authors: Silberman Et al.
Amphetamine modulation of long-term potentiation in the prefrontal cortex: dose dependency, monoaminergic contributions, and paradoxical rescue in hyperDArgic mutant.
Authors: Xu Et al.
Melanocortinergic modulation of cholecystokinin-induced suppression of feeding through extracellular signal-regulated kinase signaling in rat solitary nucleus.
Authors: Sutton Et al.
J Neurosci 2005;146:3739
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