Cytotoxic plant alkaloid with antitumor properties; prototypic DNA topoisomerase I inhibitor. Induces single strand DNA breaks and protein-DNA crosslinks.
Soluble to 5 mM in DMSO
Desiccate at +4°C
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All Tocris products are intended for laboratory research use only.
Kishimoto T et al.
Leucocyte Typing VI. Garland Publishing Inc. London.
Camptothecin derivatives induce regression of human ovarian carcinomas grown in nude mice and distinguish between non-tumorigenic and tumorigenic cells in vitro.
Pantazis et al.
DNA topoisomerase poisons as antitumour drugs.
Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.
Hsiang et al.
The citations listed below are publications that use Tocris products. Selected citations for Camptothecin include:
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