Camptothecin

Key Product Details

Product Description

Camptothecin is a cytotoxic plant alkaloid with antitumor properties; prototypic DNA topoisomerase I inhibitor. Induces single strand DNA breaks and protein-DNA crosslinks.

Product Specifications for Camptothecin

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Camptothecin

The following data is based on the product molecular weight 348.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	57.41 mL	287.06 mL	574.12 mL
0.25 mM	11.48 mL	57.41 mL	114.82 mL
0.5 mM	5.74 mL	28.71 mL	57.41 mL
2.5 mM	1.15 mL	5.74 mL	11.48 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 73 publications citing the usage of this product.

• Hsiang Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J.Biol.Chem. 1985 PMID: 2997227
• Pantazis Camptothecin derivatives induce regression of human ovarian carcinomas grown in nude mice and distinguish between non-tumorigenic and tumorigenic cells in vitro. Int.J.Cancer 1993 PMID: 8449612
• Liu DNA topoisomerase poisons as antitumour drugs. Annu.Rev.Biochem 1989 PMID: 2549853

Product Documents for Camptothecin