Catalog Number: 1100
Chemical Name: (S)-4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Biological Activity
Cytotoxic plant alkaloid with antitumor properties; prototypic DNA topoisomerase I inhibitor. Induces single strand DNA breaks and protein-DNA crosslinks.
Technical Data
  • M.Wt:
    348.36
  • Formula:
    C20H16N2O4
  • Solubility:
    Soluble to 5 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    7689-03-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References

  1. Kishimoto T et al.
    Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Camptothecin derivatives induce regression of human ovarian carcinomas grown in nude mice and distinguish between non-tumorigenic and tumorigenic cells in vitro.
    Pantazis et al.
    Int.J.Cancer, 1993;53:863
  3. DNA topoisomerase poisons as antitumour drugs.
    Liu
    Annu.Rev.Biochem, 1989;58:351
  4. Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.
    Hsiang et al.
    J.Biol.Chem., 1985;260:14873
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Camptothecin include:

5 Citations: Showing 1 - 5
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  1. CLIC5: a novel ETV6 target gene in childhood acute lymphoblastic leukemia.
    Authors: Neveu Et al.
    Haematologica 2016;
  2. Preclinical evaluation of 4-methylthiobutyl isothiocyanate on liver cancer and cancer stem cells with different p53 status.
    Authors: Lamy Et al.
    PLoS One 2013;8:e70846
  3. Cyclotides Suppress Human T-Lymphocyte Proliferation by an Interleukin 2-Dependent Mechanism.
    Authors: Gründemann Et al.
    PLoS One 2013;8:e68016
  4. Immunosuppressive activity of an aqueous Viola tricolor herbal extract.
    Authors: Hellinger Et al.
    J Ethnopharmacol 2013;151:299
  5. Oxygen-sensitive {δ}-opioid receptor-regulated survival and death signals: novel insights into neuronal preconditioning and protection.
    Authors: Ma Et al.
    Sci Rep 2005;280:16208
Tocris Small Molecules
Description Application Cat# Citations Images  

Topotecan hydrochloride

4562 1  
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