Catalog Number: 1100
Chemical Name: (S)-4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Biological Activity
Cytotoxic plant alkaloid with antitumor properties; prototypic DNA topoisomerase I inhibitor. Induces single strand DNA breaks and protein-DNA crosslinks.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 5 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References

  1. Kishimoto T et al.
    Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Camptothecin derivatives induce regression of human ovarian carcinomas grown in nude mice and distinguish between non-tumorigenic and tumorigenic cells in vitro.
    Pantazis et al.
    Int.J.Cancer, 1993;53:863
  3. DNA topoisomerase poisons as antitumour drugs.
    Annu.Rev.Biochem, 1989;58:351
  4. Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.
    Hsiang et al.
    J.Biol.Chem., 1985;260:14873
Tocris Small Molecules
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Topotecan hydrochloride

4562 1  
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