Chemical Name: 2-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol
Biological Activity(-)-Cannabidiol is a non-psychotropic constituent of cannabis that is anticonvulsive, antihyperalgesic and neuroprotective in vivo. GPR55 and weak CB1 antagonist (IC50 values are 0.445 and 3.35 μM), CB2 receptor inverse agonist and inhibitor of anandamide uptake (IC50 = 27.5 μM). Also inhibits FABPs and a weak agonist at TRP vanilloid receptors (EC50 = 3.5 μM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The orphan receptor GPR55 is a novel cannabinoid receptor.
Ryberg et al.
Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation.
Costa et al.
Complex pharmacology of natural cannabinoids: evidence for partial agonist activity of Δ9-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptors.
Petitet et al.
Life Sci., 1998;63:PL1
Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro.
Thomas et al.
A personal retrospective: Elevating Anandamide (AEA) by targeting fatty acid amide hydrolase (FAAH) and the fatty acid binding proteins (FABPs).
Citations for (-)-Cannabidiol
The citations listed below are publications that use Tocris products. Selected citations for (-)-Cannabidiol include:
5 Citations: Showing 1 - 5
Paraneoplastic cerebellar degeneration: Yo antibody alters mitochondrial calcium buffering capacity.
Authors: Panja Et al.
Neuropathol Appl Neurobiol 2019;45:141
Cannabidiol enhances MOR antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor.
Authors: Rodríguez-Muñoz Et al.
Mol Brain 2018;11:51
Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement.
Authors: Esposito Et al.
Proc Natl Acad Sci U S A 2011;6:e28668
Increasing antiproliferative properties of endocannabinoids in N1E-115 neuroblastoma cells through inhibition of their metabolism.
Authors: Hamtiaux Et al.
PLoS One 2011;6:e26823
The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo.
Authors: Whyte Et al.
PLoS One 2009;106:16511
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