Catalog Number: 2685
Alternate Names: BM 14190
Chemical Name: 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol
Biological Activity
Potent β-adrenoceptor and α1-adrenoceptor antagonist (Ki values are 0.81, 0.96 and 2.2 nM for β1-, β2- and α1-adrenoceptors respectively) that displays antihypertensive and peripheral vasodilatory activity. Blocks cardiac inward-rectifier K+ (KIR) channels, voltage-dependent Ca2+ channels and exhibits antioxidant properties at higher concentrations.
Technical Data
  • M.Wt:
    406.47
  • Formula:
    C24H26N2O4
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    72956-09-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Differential effects of bucindolol and carvedilol on noradrenaline-induced hypertonic response in ventricular cardiomyocytes of adult rats.
    Ponicke et al.
    J.Pharmacol.Exp.Ther., 2002;301:71
  2. Carvedilol blocks cardiac KATP and KG but not IK1 channels by acting at the bundle-crossing region.
    Kikuta et al.
    Eur.J.Pharmacol., 2006;529:47
  3. Carvedilol, a cardiovascular drug, prevents vascular smooth muscle cell proliferation, migration, and neointimal formation following vascular injury.
    Ohlstein et al.
    Proc.Natl.Acad.Sci.USA., 1993;90:6189
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Carvedilol include:

2 Citations: Showing 1 - 2
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  1. Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses.
    Authors: Baker Et al.
    FASEB J 2011;25:4486
  2. Blockade of adrenoreceptors inhibits the splenic response to stroke.
    Authors: Ajmo Et al.
    Nat Commun 2009;218:47

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