Catalog Number: 2685
Alternate Names: BM 14190
Chemical Name: 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol
Biological Activity
Potent β-adrenoceptor and α1-adrenoceptor antagonist (Ki values are 0.81, 0.96 and 2.2 nM for β1-, β2- and α1-adrenoceptors respectively) that displays antihypertensive and peripheral vasodilatory activity. Blocks cardiac inward-rectifier K+ (KIR) channels, voltage-dependent Ca2+ channels and exhibits antioxidant properties at higher concentrations.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Differential effects of bucindolol and carvedilol on noradrenaline-induced hypertonic response in ventricular cardiomyocytes of adult rats.
    Ponicke et al.
    J.Pharmacol.Exp.Ther., 2002;301:71
  2. Carvedilol blocks cardiac KATP and KG but not IK1 channels by acting at the bundle-crossing region.
    Kikuta et al.
    Eur.J.Pharmacol., 2006;529:47
  3. Carvedilol, a cardiovascular drug, prevents vascular smooth muscle cell proliferation, migration, and neointimal formation following vascular injury.
    Ohlstein et al.
    Proc.Natl.Acad.Sci.USA., 1993;90:6189

The citations listed below are publications that use Tocris products. Selected citations for Carvedilol include:

2 Citations: Showing 1 - 2
Filter your results:

  1. Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses.
    Authors: Baker Et al.
    FASEB J 2011;25:4486
  2. Blockade of adrenoreceptors inhibits the splenic response to stroke.
    Authors: Ajmo Et al.
    Nat Commun 2009;218:47

Have you used Carvedilol?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details


Contact Information


Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee


Customer Information