-adrenoceptor and α1
-adrenoceptor antagonist (Ki
values are 0.81, 0.96 and 2.2 nM for β1
- and α1
-adrenoceptors respectively) that displays antihypertensive and peripheral vasodilatory activity. Blocks cardiac inward-rectifier K+
) channels, voltage-dependent Ca2+
channels and exhibits antioxidant properties at higher concentrations.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Differential effects of bucindolol and carvedilol on noradrenaline-induced hypertonic response in ventricular cardiomyocytes of adult rats.
Ponicke et al.
Carvedilol blocks cardiac KATP and KG but not IK1 channels by acting at the bundle-crossing region.
Kikuta et al.
Carvedilol, a cardiovascular drug, prevents vascular smooth muscle cell proliferation, migration, and neointimal formation following vascular injury.
Ohlstein et al.
The citations listed below are publications that use Tocris products. Selected citations for Carvedilol include:
Showing Results 1 - 2 of 2