Carvedilol

Key Product Details

Product Description

Carvedilol is a potent β-adrenoceptor and α₁-adrenoceptor antagonist (K_i values are 0.81, 0.96 and 2.2 nM for β₁-, β₂- and α₁-adrenoceptors respectively) that displays antihypertensive and peripheral vasodilatory activity. Blocks cardiac inward-rectifier K⁺ (K_IR) channels, voltage-dependent Ca²⁺ channels and exhibits antioxidant properties at higher concentrations.

Product Specifications for Carvedilol

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Carvedilol

The following data is based on the product molecular weight 406.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.46 mL	12.30 mL	24.60 mL
5 mM	0.49 mL	2.46 mL	4.92 mL
10 mM	0.25 mL	1.23 mL	2.46 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 30 publications citing the usage of this product.

• Kikuta Carvedilol blocks cardiac K_ATP and K_G but not I_K1 channels by acting at the bundle-crossing region. Eur.J.Pharmacol. 2006 PMID: 16325804
• Ohlstein Carvedilol, a cardiovascular drug, prevents vascular smooth muscle cell proliferation, migration, and neointimal formation following vascular injury. Proc.Natl.Acad.Sci.USA. 1993 PMID: 8327499
• Ponicke Differential effects of bucindolol and carve. on noradrenaline-induced hypertonic response in ventricular cardiomyocytes of adult rats. J.Pharmacol.Exp.Ther. 2002 PMID: 11907159

Product Documents for Carvedilol