Chemical Name: 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol
Biological ActivityCarvedilol is a potent β-adrenoceptor and α1-adrenoceptor antagonist (Ki values are 0.81, 0.96 and 2.2 nM for β1-, β2- and α1-adrenoceptors respectively) that displays antihypertensive and peripheral vasodilatory activity. Blocks cardiac inward-rectifier K+ (KIR) channels, voltage-dependent Ca2+ channels and exhibits antioxidant properties at higher concentrations.
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Complete Your Experiment
Carvedilol blocks cardiac KATP and KG but not IK1 channels by acting at the bundle-crossing region.
Kikuta et al.
Differential effects of bucindolol and carve. on noradrenaline-induced hypertonic response in ventricular cardiomyocytes of adult rats.
Ponicke et al.
Citations for Carvedilol
The citations listed below are publications that use Tocris products. Selected citations for Carvedilol include:
3 Citations: Showing 1 - 3
Resonant waveguide grating biosensor-enabled label-free and fluorescence detection of cell adhesion.
Authors: Zaytseva Et al.
Sens Actuators B Chem 2013;188
Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses.
Authors: Baker Et al.
FASEB J 2011;25:4486
Blockade of adrenoreceptors inhibits the splenic response to stroke.
Authors: Ajmo Et al.
Nat Commun 2009;218:47
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