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Caspase-1/ICE Fluorometric Assay Kit

Catalog #: K110-100
5 Citations Datasheet / COA / SDS

Discontinued Product

K110-100 has been discontinued.
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Citations (5)
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Caspase-1/ICE Fluorometric Assay Kit Summary

Specifications

Source
N/A
Shipping Conditions
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
Multi-Species

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COA
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Background: Caspase-1

Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7).

Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases.

Entrez Gene IDs
834 (Human)
Alternate Names
CASP1 nirs variant 1; CASP1; CASP-1; caspase 1, apoptosis-related cysteine peptidase; Caspase-1 subunit p10; Caspase-1 subunit p20; Caspase1; Caspase-1; EC 3.4.22.36; EC:3.4.22.36; ICE; IL-1 beta-converting enzyme; IL1BC; IL-1BC; IL1BCE; IL1B-convertase; interleukin 1, beta, convertase; interleukin 1-B converting enzyme; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; p45

Citations for Caspase-1/ICE Fluorometric Assay Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

5 Citations: Showing 1 - 5
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  1. Alarmin S100A11 initiates a chemokine response to the human pathogen Toxoplasma gondii
    Authors: A Safronova, A Araujo, ET Camanzo, TJ Moon, MR Elliott, DP Beiting, F Yarovinsky
    Nat. Immunol., 2018-11-19;20(1):64-72.  2018-11-19
  2. NLRP3 inflammasome: Pathogenic role and potential therapeutic target for IgA nephropathy
    Authors: YL Tsai, KF Hua, A Chen, CW Wei, WS Chen, CY Wu, CL Chu, YL Yu, CW Lo, SM Ka
    Sci Rep, 2017-01-24;7(0):41123.  2017-01-24
  3. The cerebral cavernous malformation 3 gene is necessary for senescence induction.
    Authors: Guerrero A, Iglesias C, Raguz S, Floridia E, Gil J, Pombo C, Zalvide J
    Aging Cell, 2015-02-05;14(2):274-83.  2015-02-05
  4. PKCdelta-IRAK1 axis regulates oxidized LDL-induced IL-1beta production in monocytes.
    Authors: Tiwari R, Singh V, Singh A, Rana M, Verma A, Kothari N, Kohli M, Bogra J, Dikshit M, Barthwal M
    J Lipid Res, 2014-05-02;55(7):1226-1244.  2014-05-02
  5. Angiopoietin-1 upregulates de novo expression of IL-1beta and Il1-Ra, and the exclusive release of Il1-Ra from human neutrophils.
    Authors: Haddad L, Sirois M
    PLoS ONE, 2014-02-12;9(2):e88980.  2014-02-12

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