Key Product Details

Species Reactivity

Human

Applications

Western Blot, ELISA, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit

Format

BSA Free
View all Caspase-6 Primary Antibodies »

Product Specifications

Immunogen

Caspase-6 antibody was raised against a 15 amino acid synthetic peptide from near the center of human Caspase-6. The immunogen is located within amino acids 160 - 210 of Caspase-6.

Specificity

Depending on cell lines or tissues used, either full-length or other cleavage products may be observed.

Clonality

Polyclonal

Host

Rabbit

Scientific Data Images for Caspase-6 Antibody - BSA Free

Caspase-6 Antibody

Western Blot: Caspase-6 Antibody [NBP3-27875] -

Western Blot: Caspase-6 Antibody [NBP3-27875] - Western blot analysis of Caspase-6 in MCF7 cell lysate with Caspase-6 antibody (IN) at (A) 1 and (B) 2 u/mL.
Caspase-6 Antibody

Immunocytochemistry/ Immunofluorescence: Caspase-6 Antibody [NBP3-27875] -

Immunocytochemistry/ Immunofluorescence: Caspase-6 Antibody [NBP3-27875] - Immunofluorescence of Caspase 6 in MCF7 cells with Caspase 6 antibody at 10 u/mL.
Caspase-6 Antibody

Immunocytochemistry/ Immunofluorescence: Caspase-6 Antibody [NBP3-27875] -

Immunocytochemistry/ Immunofluorescence: Caspase-6 Antibody [NBP3-27875] - Immunocytochemistry of caspase-6 in MCF7 with caspase-6 antibody at 1 u/mL.

Applications for Caspase-6 Antibody - BSA Free

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

10 ug/mL

Western Blot

1 - 2 ug/mL

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Caspase-6

Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. Caspase-6 is a major apoptotic executioner (1,2). It exists as a pro-domain protein and is cleaved by caspase-3 into two active subunits, an 18 kDa and a 10 kDa subunit (3). Caspase-6 cleaves among many different intracellular proteins, nuclear lamins. Lamins play a significant role in maintaining the integrity of the cell membrane, and their cleavage results in subsequent cellular breakdown and death (4).

Alternate Names

CASP6, Caspase6, Mch2

Gene Symbol

CASP6

UniProt

P55212 (Mouse)

Additional Caspase-6 Products

Product Documents for Caspase-6 Antibody - BSA Free

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for Caspase-6 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Cysteine Proteases and Regulators

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Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs

No product specific FAQs exist for this product.

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Associated Pathways

Apoptosis Signaling Pathway Apoptosis Signaling Pathway Thumbnail