3-Phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50
= 33 μ
M). Decreases de novo
serine synthesis in cancer cells. Inhibits proliferation of cancer cell lines having high PHGDH expression levels.
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All Tocris products are intended for laboratory research use only.
Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers.
Mullarky et al.