Home / Dehydrogenase Inhibitors / CBR 5884

CBR 5884

Catalog #: 5836
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5836/10
5836/50
CBR 5884 | CAS No. 681159-27-3 | Dehydrogenase Inhibitors
1 Image
Description: Phosphoglycerate dehydrogenase (PHGDH) inhibitor

Chemical Name: Ethyl 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-2-thiophenecarboxylate

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

CBR 5884 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50 = 33 μM). Decreases de novo serine synthesis in cancer cells. Inhibits proliferation of cancer cell lines having high PHGDH expression levels.

Technical Data

M.Wt:
336.39
Formula:
C14H12N2O4S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
681159-27-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for CBR 5884

The citations listed below are publications that use Tocris products. Selected citations for CBR 5884 include:

2 Citations: Showing 1 - 2

  1. EWS-FLI1 reprograms the metabolism of Ewing sarcoma cells via positive regulation of glutamine import and serine-glycine biosynthesis.
    Authors: Sen Et al.
    Mol Carcinog  2018;57:1342
  2. Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production.
    Authors: Nigdelioglu Et al.
    J Biol Chem  2016;291:27239

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for CBR 5884

There are currently no reviews for this product. Be the first to review CBR 5884 and earn rewards!

Have you used CBR 5884?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.