Chemical Name: Ethyl 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-2-thiophenecarboxylate
Biological ActivityCBR 5884 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50 = 33 μM). Decreases de novo serine synthesis in cancer cells. Inhibits proliferation of cancer cell lines having high PHGDH expression levels.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers.
Mullarky et al.
Citations for CBR 5884
The citations listed below are publications that use Tocris products. Selected citations for CBR 5884 include:
2 Citations: Showing 1 - 2
EWS-FLI1 reprograms the metabolism of Ewing sarcoma cells via positive regulation of glutamine import and serine-glycine biosynthesis.
Authors: Sen Et al.
Mol Carcinog 2018;57:1342
Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production.
Authors: Nigdelioglu Et al.
J Biol Chem 2016;291:27239
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