Catalog Number: 5233
Chemical Name: N-[2-[(4-Chlorophenyl)amino]-1-methyl-2-oxoethoxy]-3,5-bis(trifluoromethyl)benzamide
Biological Activity
Rho/SRF pathway inhibitor; stimulates apoptosis of a melanoma cell line overexpressing RhoC (A375M2). Suppresses Rho-dependent invasion of PC-3 prostate cancer cells in vitro and inhibits lysophosphatidic acid-induced DNA synthesis in PC-3 prostate cancer cells. When used in combination with Retinoic acid, LY 294002 and Pyridone 6, it induces intermediate mesoderm differentiation from ESCs.
Technical Data
  • M.Wt:
    454.75
  • Formula:
    C18H13ClF6N2O3
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    285986-88-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Combination of small molecules enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells.
    Mae et al.
    Biochem.Biophys.Res.Commun., 2010;393:877
  2. CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling.
    Evelyn et al.
    Mol.Cancer Ther., 2007;6:2249

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