Rho/SRF pathway inhibitor; stimulates apoptosis of a melanoma cell line overexpressing RhoC (A375M2). Suppresses Rho-dependent invasion of PC-3 prostate cancer cells in vitro
and inhibits lysophosphatidic acid-induced DNA synthesis in PC-3 prostate cancer cells. When used in combination with Retinoic acid
, LY 294002
and Pyridone 6, it induces intermediate mesoderm differentiation from ESCs.
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Combination of small molecules enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells.
Mae et al.
CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling.
Evelyn et al.
Mol.Cancer Ther., 2007;6:2249