Chemical Name: [N-(4-Chlorophenyl)]-α-[(4-chlorophenyl)-aminomethylene]-3-methyl-5-isoxazoleacetamide
Biological ActivityCCMI is a positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors (nAChR). Evokes positive modulation of acetylcholine (ACh)-induced EC5 currents (EC50 = 0.7 μM). Exhibits cognitive-enhancing properties in rodent models; displays no cytotoxic effects in PC12 cells or rat primary cortical neurons.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Distinct profiles of α7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes.
Gronlien et al.
Positive allosteric modulation of α7 neuronal nicotinic acetylcholine receptors: lack of cytotoxicity in PC12 cells and rat primary cortical neurons.
Hu et al.
Nootropic α7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators.
Ng et al.
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