CCMI

Key Product Details

Product Description

CCMI is a positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors (nAChR). Evokes positive modulation of acetylcholine (ACh)-induced EC₅ currents (EC₅₀ = 0.7 μM). Exhibits cognitive-enhancing properties in rodent models; displays no cytotoxic effects in PC12 cells or rat primary cortical neurons.

Product Specifications for CCMI

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CCMI

The following data is based on the product molecular weight 388.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.58 mL	12.88 mL	25.76 mL
5 mM	0.52 mL	2.58 mL	5.15 mL
10 mM	0.26 mL	1.29 mL	2.58 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Hu Positive allosteric modulation of α7 neuronal nicotinic acetylcholine receptors: lack of cytotoxicity in PC12 cells and rat primary cortical neurons. Br.J.Pharmacol. 2009 PMID: 20050184
• Ng Nootropic α7 nicotinic receptor allosteric modulator derived from GABA_A receptor modulators. Proc.Natl.Acad.Sci.U.S.A. 2007 PMID: 17470817
• Gronlien Distinct profiles of α₇ nAChR positive allosteric modulation revealed by structurally diverse chemotypes. Mol.Pharmacol. 2007 PMID: 17565004

Product Documents for CCMI