CCMI

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CCMI | CAS No. 917837-54-8 | Nicotinic (a7) Receptor Modulators
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Description: Positive allosteric modulator of α7 nAChRs
Alternative Names: XY 4083

Chemical Name: [N-(4-Chlorophenyl)]-α-[(4-chlorophenyl)-aminomethylene]-3-methyl-5-isoxazoleacetamide

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Biological Activity

Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors (nAChR). Evokes positive modulation of acetylcholine (ACh)-induced EC5 currents (EC50 = 0.7 μM). Exhibits cognitive-enhancing properties in rodent models; displays no cytotoxic effects in PC12 cells or rat primary cortical neurons.

Technical Data

M.Wt:
388.25
Formula:
C19H15Cl2N3O2
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Storage:
Store at -20°C
CAS No:
917837-54-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Distinct profiles of α7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes.
    Gronlien et al.
    Mol.Pharmacol., 2007;72:715
  2. Positive allosteric modulation of α7 neuronal nicotinic acetylcholine receptors: lack of cytotoxicity in PC12 cells and rat primary cortical neurons.
    Hu et al.
    Br.J.Pharmacol., 2009;158:1857
  3. Nootropic α7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators.
    Ng et al.
    Proc.Natl.Acad.Sci., 2007;104:8059

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