CCT 031374 hydrobromide
Chemical Name: 1-[1,1'-Biphenyl]-4-yl-2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)ethanone hydrobromide
Biological ActivityCCT 031374 hydrobromide is an inhibitor of TCF-dependent transcription. Blocks BIO-induced β-catenin stabilization; reduces nuclear and cytosolic β-catenin levels in mouse L-cells. Inhibits growth and reduces TCF-dependent transcription in SW480 colon carcinoma cells.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription.
Ewan et al.
Cancer Res., 2010;70:5963
Citations for CCT 031374 hydrobromide
The citations listed below are publications that use Tocris products. Selected citations for CCT 031374 hydrobromide include:
2 Citations: Showing 1 - 2
Aging differentially modulates the Wnt pro-survival signalling pathways in vascular smooth muscle cells.
Authors: Brown Et al.
Aging Cell 2019;18:e12844
β-catenin signaling induces the osteoblastogenic differentiation of human pre-osteoblastic and bone marrow stromal cells mainly through the upregulation of osterix expression.
Authors: Liu Et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for CCT 031374 hydrobromide
There are currently no reviews for this product. Be the first to review CCT 031374 hydrobromide and earn rewards!
Have you used CCT 031374 hydrobromide?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image