Inhibitor of TCF-dependent transcription. Blocks BIO
-catenin stabilization; reduces nuclear and cytosolic β
-catenin levels in mouse L-cells. Inhibits growth and reduces TCF-dependent transcription in SW480 colon carcinoma cells.
Soluble to 50 mM in DMSO
Desiccate at RT
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A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription.
Ewan et al.
Cancer Res., 2010;70:5963
The citations listed below are publications that use Tocris products. Selected citations for CCT 031374 hydrobromide include:
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