CCT 031374 hydrobromide
Chemical Name: 1-[1,1'-Biphenyl]-4-yl-2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)ethanone hydrobromide
Biological ActivityInhibitor of TCF-dependent transcription. Blocks BIO-induced β-catenin stabilization; reduces nuclear and cytosolic β-catenin levels in mouse L-cells. Inhibits growth and reduces TCF-dependent transcription in SW480 colon carcinoma cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription.
Ewan et al.
Cancer Res., 2010;70:5963
Citation for CCT 031374 hydrobromide
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