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CCT 031374 hydrobromide

4675 2 Citations Datasheet / COA / SDS
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4675/50
CCT 031374 hydrobromide | CAS No. 1219184-91-4 | beta-Catenin Inhibitors
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Description: Inhibits TCF-dependent transcription; lowers β-catenin levels

Chemical Name: 1-[1,1'-Biphenyl]-4-yl-2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)ethanone hydrobromide

Product Details
Citations (2)
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Biological Activity

Inhibitor of TCF-dependent transcription. Blocks BIO-induced β-catenin stabilization; reduces nuclear and cytosolic β-catenin levels in mouse L-cells. Inhibits growth and reduces TCF-dependent transcription in SW480 colon carcinoma cells.

Technical Data

Formula:
C23H19N3O.HBr
Solubility:
Soluble to 50 mM in DMSO
Storage:
Store the unopened product at room temperature. Do not use past expiration date.
CAS No:
1219184-91-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for CCT 031374 hydrobromide

The citations listed below are publications that use Tocris products. Selected citations for CCT 031374 hydrobromide include:

2 Citations: Showing 1 - 2

  1. Aging differentially modulates the Wnt pro-survival signalling pathways in vascular smooth muscle cells.
    Authors: Brown Et al.
    Aging Cell  2019;18:e12844
  2. β-catenin signaling induces the osteoblastogenic differentiation of human pre-osteoblastic and bone marrow stromal cells mainly through the upregulation of osterix expression.
    Authors: Liu Et al.
    Nature  2015;36:1572

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VersaClone cDNA Plasmids

Human beta-Catenin (NP_001895) VersaClone cDNA

RDC2388

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