CCT 031374 hydrobromide
Chemical Name: 1-[1,1'-Biphenyl]-4-yl-2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)ethanone hydrobromide
Biological ActivityInhibitor of TCF-dependent transcription. Blocks BIO-induced β-catenin stabilization; reduces nuclear and cytosolic β-catenin levels in mouse L-cells. Inhibits growth and reduces TCF-dependent transcription in SW480 colon carcinoma cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription.
Ewan et al.
Cancer Res., 2010;70:5963
Citations for CCT 031374 hydrobromide
The citations listed below are publications that use Tocris products. Selected citations for CCT 031374 hydrobromide include:
2 Citations: Showing 1 - 2
Aging differentially modulates the Wnt pro-survival signalling pathways in vascular smooth muscle cells.
Authors: Brown Et al.
Aging Cell 2019;18:e12844
β-catenin signaling induces the osteoblastogenic differentiation of human pre-osteoblastic and bone marrow stromal cells mainly through the upregulation of osterix expression.
Authors: Liu Et al.
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VersaClone cDNA Plasmids
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