CCT 241533 dihydrochloride

Tocris Bioscience | Catalog # 4968

Potent Chk2 inhibitor
Tocris Bioscience
Discontinued Product
4968 has been discontinued. View all Checkpoint Kinase Inhibitors products.

Key Product Details

Description

Potent Chk2 inhibitor
View all Checkpoint Kinase Inhibitors »

Product Description

CCT 241533 dihydrochloride is a potent Chk2 inhibitor (IC50 = 3 nM). Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells. Blocks ionizing radiation-induced apoptosis of mouse thymocytes.

Licensing Information

Sold under license from Cancer Research Technology Ltd (Ximbio).

External Portal Information

Chemicalprobes.org

is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of CCT 241533 is reviewed on the chemical probes website.

Product Specifications for CCT 241533 dihydrochloride

Molecular Weight

515.41

Formula

C23H27FN4O4.2HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

(3R,4S)-4-[[2-(5-Fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-α,α-dimethyl-3-pyrrolidinemethanol dihydrochloride

CAS Number

1962925-28-5

PubChem ID

49867844

InChI Key

IXTQNANZDPZION-GSOOIIRJSA-N

SMILES

FC1=CC(C3=NC2=CC(OC)=C(OC)C=C2C(N[C@H]4[C@H]([C@](C)(O)C)CNC4)=N3)=C(O)C=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 5.15 10 with gentle warming
DMSO 51.54 100

Preparing Stock Solutions for CCT 241533 dihydrochloride

The following data is based on the product molecular weight 515.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.94 mL 9.70 mL 19.40 mL
5 mM 0.39 mL 1.94 mL 3.88 mL
10 mM 0.19 mL 0.97 mL 1.94 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

Product Documents for CCT 241533 dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CCT 241533 dihydrochloride

For research use only

Citations for CCT 241533 dihydrochloride

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