Catalog Number: 1226
Chemical Name: [5R-[5α,5aβ,8aα,9β(R*)]]-9-[(4,6-Ο-Ethylidene-β-D-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6-(5aH)-one
Biological Activity
Topoisomerase II inhibitor (IC50 = 59.2 μM).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Toposiomerase II.etoposide interactions direct the formation of drug-induced enzyme-DNA cleavage complexes.
    Burden et al.
    J.Biol.Chem., 1996;271:29238
  2. Etoposide: four decades of development of a topoisomerase II inhibitor.
    Hande et al.
    Eur.J.Cancer, 1998;34:1514
  3. Antitumor agents.3.Synthesis and biological activity of 4β-alkyl derivatives containing hydroxy, amino, and amido groups of 4'-O-demethyl-4-desoxypodophyllotoxin as antitumor agents.
    Terada et al.
    J.Med.Chem., 1993;36:1689

The citations listed below are publications that use Tocris products. Selected citations for Etoposide include:

Showing Results 1 - 2 of 2

  1. Etoposide incorporated into camel milk phospholipids liposomes shows increased activity against fibrosarcoma in a mouse model.
    Authors: Maswadeh Et al.
    Eur J Cancer
  2. Transmembrane Protein 214 (TMEM214) mediates endoplasmic reticulum stress-induced caspase 4 enzyme activation and apoptosis.
    Authors: Li Et al.
    J Biol Chem
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