Catalog Number: 4737
Chemical Name: 1-(2-Cyano-3,12,28-trioxooleana-1,9(11)-dien-28-yl)-1H-imidazole
Biological Activity
Nrf2 signaling activator; increases Nrf2 protein expression and enhances Nrf2-dependent cytoprotective gene expression. Inhibits cell growth and induces apoptosis of pancreatic cancer cells in vitro. Also reduces acetaminophen-induced liver injury in mice.
Technical Data
  • M.Wt:
    541.72
  • Formula:
    C34H43N3O3
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    443104-02-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes.
    Reisman et al.
    Toxicol.Appl.Pharmacol., 2009;236:109
  2. 2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer.
    Samudio et al.
    J.Biol.Chem., 2005;280:36273
  3. Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity.
    Aleksunes et al.
    J.Pharmacol.Exp.Ther., 2010;335:2

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