Catalog # Availability Size / Price Qty
CDDO Im | CAS No. 443104-02-7 | Nrf2 Activators
1 Image
Description: Nrf2 signaling activator

Chemical Name: 1-(2-Cyano-3,12,28-trioxooleana-1,9(11)-dien-28-yl)-1H-imidazole

Purity: ≥98%

Product Details
Citations (4)

Biological Activity

CDDO Im is an Nrf2 signaling activator; increases Nrf2 protein expression and enhances Nrf2-dependent cytoprotective gene expression. CDDO Im inhibits cell growth and induces apoptosis of pancreatic cancer cells in vitro. Also reduces acetaminophen-induced liver injury in mice.

Technical Data

Soluble to 100 mM in DMSO
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Nrf2 Suppresses Allergic Lung Inflammation by Attenuating the Type 2 Innate Lymphoid Cell Response
    R Nagashima, H Kosai, M Masuo, K Izumiyama, T Noshikawaj, M Morimoto, S Kumaki, Y Miyazaki, H Motohashi, M Yamamoto, N Tanaka
    J. Immunol., 2019;0(0):.
  2. Macrophages Switch Their Phenotype by Regulating Maf Expression during Different Phases of Inflammation
    K Kikuchi, M Iida, N Ikeda, S Moriyama, M Hamada, S Takahashi, H Kitamura, T Watanabe, Y Hasegawa, K Hase, T Fukuhara, H Sato, EH Kobayashi, T Suzuki, M Yamamoto, M Tanaka, K Asano
    J. Immunol., 2018;0(0):.
  3. CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes.
    Reisman et al.
    Toxicol.Appl.Pharmacol., 2009;236:109
  4. 2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer.
    Samudio et al.
    J.Biol.Chem., 2005;280:36273
  5. Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity.
    Aleksunes et al.
    J.Pharmacol.Exp.Ther., 2010;335:2

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Citations for CDDO Im

The citations listed below are publications that use Tocris products. Selected citations for CDDO Im include:

4 Citations: Showing 1 - 4


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