Nrf2 signaling activator; increases Nrf2 protein expression and enhances Nrf2-dependent cytoprotective gene expression. Inhibits cell growth and induces apoptosis of pancreatic cancer cells in vitro
. Also reduces acetaminophen
-induced liver injury in mice.
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All Tocris products are intended for laboratory research use only.
CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes.
Reisman et al.
2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer.
Samudio et al.
Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity.
Aleksunes et al.