Catalog Number: 1706
Alternate Names: Paracetamol
Chemical Name: N-(4-Hydroxyphenyl)acetamide
Biological Activity
Cyclooxygenase inhibitor; may be selective for COX-3 (IC50 values are 460, > 1000 and > 1000 μM for canine COX-3, and murine COX-1 and COX-2 respectively). Widely used analgesic and antipyretic agent.
Technical Data
  • M.Wt:
    151.16
  • Formula:
    C8H9NO2
  • Solubility:
    Soluble to 100 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    103-90-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression.
    Chandrasekharan et al.
    Proc.Natl.Acad.Sci.U.S.A., 2002;99:13926
  2. Effect of acetaminophen on atherosclerosis.
    Chong et al.
    Ann.Pharmacother., 2001;35:1476
  3. Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal anti-inflammatory drugs (NSAIDS) and selective COX-2 inhibitors, using sensitive microsomal and platelet assays.
    Riendeau et al.
    Can.J.Physiol.Pharmacol., 1997;75:1088
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Acetaminophen include:

2 Citations: Showing 1 - 2
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  1. Evaluation of drug-induced tissue injury by measuring alanine aminotransferase (ALT) activity in silkworm hemolymph.
    Authors: Inagaki Et al.
    J Neurosci 2012;13:13
  2. Adenosine regulation of alveolar fluid clearance.
    Authors: Factor Et al.
    Proc Natl Acad Sci U S A 2007;104:4083

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