Cyclooxygenase inhibitor; may be selective for COX-3 (IC50
values are 460, > 1000 and > 1000 μ
M for canine COX-3, and murine COX-1 and COX-2 respectively). Widely used analgesic and antipyretic agent.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression.
Chandrasekharan et al.
Effect of acetaminophen on atherosclerosis.
Chong et al.
Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal anti-inflammatory drugs (NSAIDS) and selective COX-2 inhibitors, using sensitive microsomal and platelet assays.
Riendeau et al.
The citations listed below are publications that use Tocris products. Selected citations for Acetaminophen include:
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