Antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF-α
B activation. Also shown to inhibit topoisomerase II activity in vitro
= 7.41 μ
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All Tocris products are intended for laboratory research use only.
Apoptosis induction in HL-60 cells and inhibition of topoisomerase II by triterpene celastrol.
Nagase et al.
Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-κB-regulated gene products and TAK1-mediated NF-κB activation.
Sethi et al.
The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria.
Sassa et al.
The citations listed below are publications that use Tocris products. Selected citations for Celastrol include:
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