Chemical Name: (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid
Biological ActivityAntioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF-α-induced NFκB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 μM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Apoptosis induction in HL-60 cells and inhibition of topoisomerase II by triterpene celastrol.
Nagase et al.
Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-κB-regulated gene products and TAK1-mediated NF-κB activation.
Sethi et al.
The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria.
Sassa et al.
Citation for Celastrol
The citations listed below are publications that use Tocris products. Selected citations for Celastrol include:
1 Citation: Showing 1 - 1
Interleukin 34: a new modulator of human and experimental inflammatory bowel disease.
Authors: Zwicker Et al.
Clin Sci (Lond) 2015;129:281
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for Celastrol
There are currently no reviews for this product. Be the first to review Celastrol and earn rewards!
Have you used Celastrol?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image