Celastrol

Catalog # Availability Size / Price Qty
3203/10
3203/50
Cat.No. 3203 - Celastrol | C29H38O4 | CAS No. 34157-83-0
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Description: Inhibits TNF-α-induced NF-κB activation

Chemical Name: (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid

Purity: ≥99%

Product Details
Citations (1)
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Biological Activity

Antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF-α-induced NFκB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 μM).

Technical Data

M.Wt:
450.61
Formula:
C29H38O4
Solubility:
Soluble to 100 mM in DMSO and to 75 mM in ethanol
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
34157-83-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Apoptosis induction in HL-60 cells and inhibition of topoisomerase II by triterpene celastrol.
    Nagase et al.
    Biosci.Biotechnol.Biochem., 2003;67:1883
  2. Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-κB-regulated gene products and TAK1-mediated NF-κB activation.
    Sethi et al.
    Blood, 2007;109:2727
  3. The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria.
    Sassa et al.
    Biochem.Biophys.Res.Comms., 1990;172:890

Product Datasheets

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Citation for Celastrol

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