Centrinone

Tocris Bioscience | Catalog # 5687

High affinity and selective PLK4 inhibitor
Tocris Bioscience

Key Product Details

Description

High affinity and selective PLK4 inhibitor
View all Polo-like Kinase Inhibitors »

Product Description

Centrinone is a high affinity and selective PLK4 inhibitor (Ki = 0.16 nM). Exhibits >1000-fold selectivity for PLK4 over Aurora A and Aurora B. Depletes centriole and centrosome levels in vitro. Induces cell cycle arrest in normal human cell lines in a p53-dependent manner. Decreases expression of pluripotency markers and induces differentiation in pluripotent stem cells.

Licensing Information

Sold with the permission of the Ludwig Institute for Cancer Research Ltd

Product Specifications for Centrinone

Molecular Weight

633.65

Formula

C26H25F2N7O6S2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2-[[2-Fluoro-4-[[(2-fluoro-3-nitrophenyl)methyl]sulfonyl]phenyl]thio]-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-(4-morpholinyl)-4-pyrimidinamine

CAS Number

1798871-30-3

PubChem ID

91801159

InChI Key

HHJSKDRCUMVWKF-UHFFFAOYSA-N

SMILES

FC1=C([N+]([O-])=O)C=CC=C1CS(C2=CC=C(SC3=NC(N4CCOCC4)=C(OC)C(NC5=NNC(C)=C5)=N3)C(F)=C2)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.68 50

Preparing Stock Solutions for Centrinone

The following data is based on the product molecular weight 633.65.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.16 mL 15.78 mL 31.56 mL
2.5 mM 0.63 mL 3.16 mL 6.31 mL
5 mM 0.32 mL 1.58 mL 3.16 mL
25 mM 0.06 mL 0.32 mL 0.63 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 28 publications citing the usage of this product.

Product Documents for Centrinone

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Centrinone

For research use only

Related Research Areas

Intracellular Kinases

Customer Reviews for Centrinone (1)

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  • Nup188 recruitment to the centrosomes
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Cell Line/Tissue: HeLa
    Verified Customer | Posted 06/11/2019
    I have used this product in HeLa cells to abolish centrosomes and then track the recruitment kinetics of centriole biogenesis

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