Centrinone

Catalog # Availability Size / Price Qty
5687/10

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Centrinone | CAS No. 1798871-30-3 | Polo-like Kinase Inhibitors
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Description: High affinity and selective PLK4 inhibitor

Chemical Name: 2-[[2-Fluoro-4-[[(2-fluoro-3-nitrophenyl)methyl]sulfonyl]phenyl]thio]-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-(4-morpholinyl)-4-pyrimidinamine

Purity: ≥98%

Product Details
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Biological Activity

Centrinone is a high affinity and selective PLK4 inhibitor (Ki = 0.16 nM). Exhibits >1000-fold selectivity for PLK4 over Aurora A and Aurora B. Depletes centriole and centrosome levels in vitro. Induces cell cycle arrest in normal human cell lines in a p53-dependent manner. Decreases expression of pluripotency markers and induces differentiation in pluripotent stem cells.

Technical Data

M.Wt:
633.65
Formula:
C26H25F2N7O6S2
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1798871-30-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of the Ludwig Institute for Cancer Research Ltd

Product Datasheets

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