High affinity and selective PLK4 inhibitor (Ki
= 0.16 nM). Exhibits >1000-fold selectivity for PLK4 over Aurora A and Aurora B. Depletes centriole and centrosome levels in vitro
. Induces cell cycle arrest in normal human cell lines in a p53-dependent manner.
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Reversible centriole depletion with an inhibitor of Polo-like kinase 4.
Wong et al.