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CEP 1347

4924 1 Citation Datasheet / COA / SDS
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4924/1
CEP 1347 | CAS No. 156177-65-0 | JNK/c-jun Inhibitors
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Description: Inhibitor of JNK signaling

Chemical Name: (9S,10R,12R)-5-16-Bis[(ethylthio)methyl]-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester

Purity: ≥97%

Product Details
Citations (1)
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Biological Activity

Inhibitor of c-jun N-terminal kinase (JNK) signaling. Rescues motor neurons undergoing apoptosis (EC50 = 20 nM). Blocks Aβ-induced cortical neuron apoptosis (EC50 ~51 nM). Does not inhibit ERK1 activity. Neuroprotective.

Technical Data

M.Wt:
615.76
Formula:
C33H33N3O5S2
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
156177-65-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for CEP 1347

The citations listed below are publications that use Tocris products. Selected citations for CEP 1347 include:

1 Citation: Showing 1 - 1

  1. WDR62 mediates TNFα-dependent JNK activation via TRAF2-MLK3 axis.
    Authors: Prinz Et al.
    Mol Biol Cell  2018;29:2470

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