Chemical Name: 1-[[3,4-Dihydro-6-[(2-methoxy-4-propylphenyl)methoxy]-1-methyl-2-naphthalenyl]methyl]-3-azetidinecarboxylic acid
Biological ActivityHighly potent and selective S1P1 and S1P5 agonist (EC50 values are 0.027 and 0.33 nM, respectively, in a cAMP assay). Ki values are 0.574, 0.626, 28.7 >5450 and >5630 nM for S1P5, S1P1, S1P4, S1P2, S1P3, respectively. Reduces peripheral lymphocyte count in a mouse EAE model. Orally bioavailable.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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