Ceralifimod

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6690/10
Ceralifimod | CAS No. 891859-12-4 | Sphingosine-1-phosphate Receptor Agonists
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Description: Highly potent and selective S1P1 and S1P5 agonist

Chemical Name: 1-[[3,4-Dihydro-6-[(2-methoxy-4-propylphenyl)methoxy]-1-methyl-2-naphthalenyl]methyl]-3-azetidinecarboxylic acid

Purity: ≥95%

Product Details
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Biological Activity

Highly potent and selective S1P1 and S1P5 agonist (EC50 values are 0.027 and 0.33 nM, respectively, in a cAMP assay). Ki values are 0.574, 0.626, 28.7 >5450 and >5630 nM for S1P5, S1P1, S1P4, S1P2, S1P3, respectively. Reduces peripheral lymphocyte count in a mouse EAE model. Orally bioavailable.

Technical Data

M.Wt:
435.56
Formula:
C27H33NO4
Solubility:
Soluble to 10 mM in DMSO with gentle warming
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
891859-12-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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