Catalog Number: 3536
Biological Activity
Potent gonadotropin-releasing hormone (GnRH) receptor antagonist (KD = 0.202 nM, IC50 = 1.21 nM). Suppresses production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland, which inhibits ovulation. Exhibits antiproliferative effects and displays efficacy against hormone-sensitive cancers in vivo. Also exhibits anxiolytic and antidepressant activity in vivo.
Technical Data
  • M.Wt:
    1491.11
  • Formula:
    C70H92ClN17O14.C2H4O2
  • Sequence:
    XFASYXLRPA

    (Modifications: X-1 = D-2-Nal and N-terminal Ac, Phe-2 = D-(4-Cl-Phe), Ala-3 = D-(3-Pyridyl-Ala), X-6 = D-Cit, Ala-10 = D-Ala and C-terminal amide)

  • Solubility:
    Soluble in water
  • Storage:
    Store at -20°C
  • CAS No:
    145672-81-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer.
    Grundker and Emons
    Reprod.Biol.Endocrinol., 2003;1:65
  2. Effects of the LHRH antagonist cetrorelix on the brain function in mice.
    Telegdy et al.
    Neuropeptides, 2009;43:229
  3. Characterization of gonadotropin-releasing hormone analogs based on a sensitive cellular luciferase reporter gene assay.
    Beckers et al.
    Anal.Biochem., 1997;251:17

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