Cetrorelix Acetate

Name: Cetrorelix Acetate
Brand: Tocris Bioscience
SKU: 3536

Tocris Bioscience | Catalog # 3536

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Citations (5)

Product Documents

Potent GnRH receptor antagonist

Discontinued Product

3536 has been discontinued. An alternative/replacement product is available: 8821. View all GnRH Antagonist products.

Product Description
Product Specifications
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent GnRH receptor antagonist

View all GnRH Antagonist »

Product Description

Cetrorelix Acetate is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist (K_D = 0.202 nM, IC₅₀ = 1.21 nM). Suppresses production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland, which inhibits ovulation. Exhibits antiproliferative effects and displays efficacy against hormone-sensitive cancers in vivo. Also exhibits anxiolytic and antidepressant activity in vivo.

Product Specifications for Cetrorelix Acetate

Molecular Weight

1491.11

Formula

C₇₀H₉₂ClN₁₇O₁₄.C₂H₄O₂

Storage

Store at -20°C

CAS Number

145672-81-7

PubChem ID

25078429

InChI Key

KFEFLCOCAHJBEA-ANRVCLKPSA-N

SMILES

CC(O)=O.CC(C)C[C@H](NC(=O)[C@@H](CCCNC(N)=O)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(=O)[C@@H](CC1=CN=CC=C1)NC(=O)[C@@H](CC1=CC=C(Cl)C=C1)NC(=O)[C@@H](CC1=CC2=C(C=CC=C2)C=C1)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

Grundker and Emons Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer. Reprod.Biol.Endocrinol. 2003 PMID: 14594454
Telegdy Effects of the LHRH antagonist cetro. on the brain function in mice. Neuropeptides 2009 PMID: 19375162
Beckers Characterization of gonadotropin-releasing hormone analogs based on a sensitive cellular luciferase reporter gene assay. Anal.Biochem. 1997 PMID: 9300077

Product Documents for Cetrorelix Acetate

Certificate of Analysis

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Download SDS

Product Specific Notices for Cetrorelix Acetate

For research use only

Citations for Cetrorelix Acetate

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