Biological ActivityCetrorelix Acetate is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist (KD = 0.202 nM, IC50 = 1.21 nM). Suppresses production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland, which inhibits ovulation. Exhibits antiproliferative effects and displays efficacy against hormone-sensitive cancers in vivo. Also exhibits anxiolytic and antidepressant activity in vivo.
(Modifications: X-1 = D-2-Nal and N-terminal Ac, Phe-2 = D-(4-Cl-Phe), Ala-3 = D-(3-Pyridyl-Ala), X-6 = D-Cit, Ala-10 = D-Ala and C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Characterization of gonadotropin-releasing hormone analogs based on a sensitive cellular luciferase reporter gene assay.
Beckers et al.
Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer.
Grundker and Emons
Effects of the LHRH antagonist cetro. on the brain function in mice.
Telegdy et al.
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