CFTRinh 172

Catalog # Availability Size / Price Qty
CFTRinh 172 | CAS No. 307510-92-5 | CFTR Blockers
1 Image
Description: Voltage-independent, selective CFTR chloride channel blocker

Chemical Name: 4-[[4-Oxo-2-thioxo-3-[3-trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]benzoic acid

Purity: ≥98%

Product Details
Citations (5)

Biological Activity

CFTRinh 172 is a voltage-independent, selective CFTR chloride channel blocker (Ki = 300 nM) that alters channel gating. Blocks intestinal fluid secretion induced by cholera toxin and Escherichia coli and suppresses cyst growth in animal models of polycystic kidney disease. Orally active. Inhibits mitochondrial respiration and increases reactive oxygen species (ROS) production independently of CFTR in several cell lines.

Technical Data

Soluble to 100 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion.
    Ma et al.
    J.Clin.Invest., 2002;110:1651
  2. Altered channel gating mechanism for CFTR inhibition by a high-affinity thiazolidinone blocker.
    Taddei et al.
    FEBS Lett., 2004;558:52
  3. Small-molecule CFTR inhibitors slow cyst growth in polycystic kidney disease.
    Yang et al.
    J.Am.Soc.Nephrol., 2008;19:1300
  4. Rescue of functional F508del cystic fibrosis transmembrane conductance regulator by vasoactive intestinal peptide in the human nasal epithelial cell line JME/CF15.
    Rafferty et al.
    J.Pharmacol.Exp.Ther., 2009;331:2
  5. Cystic fibrosis transmembrane regulator inhibitors CFTRinh-172 and GlyH-101 target mitochondrial functions, independently of chloride channel inhibition.
    Kelly et al.
    J.Pharmaco.Exp.Ther., 2010;333:60

Product Datasheets

Or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for CFTRinh 172

The citations listed below are publications that use Tocris products. Selected citations for CFTRinh 172 include:

5 Citations: Showing 1 - 5


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for CFTRinh 172

There are currently no reviews for this product. Be the first to review CFTRinh 172 and earn rewards!

Have you used CFTRinh 172?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.