Catalog Number: 1134
Chemical Name: 4-[3-[(1,1-Dimethylethyl)amino]2-hydroxypropoxy]-1,3-dihydro-2H-benzimidazol-2-one hydrochloride
Biological Activity
Partial agonist at β3-adrenoceptors. β1- and β2-adrenoceptor antagonist (Ki values are 0.9, 4 and 88 nM for β1, β2 and β3 receptors respectively).
Technical Data
  • M.Wt:
    315.8
  • Formula:
    C14H21N3O3.HCl
  • Solubility:
    Soluble to 50 mM in water
  • Storage:
    Store at RT
  • CAS No:
    64208-32-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Function and regulation of the β3-adrenoceptor.
    Strosberg and Pietri-Rouxel
    TiPS, 1996;17:373
  2. On the presence of a putative fourth β-adrenoceptor in human adipose tissue.
    Galitzky et al.
    TiPS, 1998;19:164
  3. Metabolic response to various β-adrenoceptor agonists in β3-adrenoceptor knockout mice: evidence for a new β-adrenergic receptor in brown adipose tissue.
    Preitner et al.
    Br.J.Pharmacol., 1998;124:1684
  4. CGP-12177. A hydrophilic beta-adrenergic receptor radioligand reveals high affinity binding of agonists to intact cells.
    Staehelin et al.
    J.Biol.Chem., 1983;258:3496
Citations:

The citations listed below are publications that use Tocris products. Selected citations for CGP 12177 hydrochloride include:

5 Citations: Showing 1 - 5
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  1. Recruitment of β-arrestin 1 and 2 to the β2-adrenoceptor: analysis of 65 ligands.
    Authors: Littmann Et al.
    Proc Natl Acad Sci U S A 2015;355:183
  2. Negative cooperativity across β1-adrenoceptor homodimers provides insights into the nature of the secondary low-affinity CGP 12177 β1-adrenoceptor binding conformation.
    Authors: Gherbi Et al.
    FASEB J 2015;29:2859
  3. Application of BRET to monitor ligand binding to GPCRs.
    Authors: Stoddart Et al.
    Nat Methods 2015;12:661
  4. Oleoylethanolamide enhances β-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat.
    Authors: Suárez Et al.
    Dis Model Mech 2014;7:129
  5. Detection of the secondary, low-affinity β1 -adrenoceptor site in living cells using the fluorescent CGP 12177 derivative BODIPY-TMR-CGP.
    Authors: Gherbi Et al.
    Br J Pharmacol 2014;171:5431

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