CGP 12177 hydrochloride

  ( 5 citations )    
Product Datasheet
Catalog Number:1134
Chemical Name:4-[3-[(1,1-Dimethylethyl)amino]2-hydroxypropoxy]-1,3-dihydro-2H-benzimidazol-2-one hydrochloride
Product Details
Citations (5)
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Reviews
Biological Activity
Partial agonist at β3-adrenoceptors. β1- and β2-adrenoceptor antagonist (Ki values are 0.9, 4 and 88 nM for β1, β2 and β3 receptors respectively).
Technical Data
  • M.Wt:
    315.8
  • Formula:
    C14H21N3O3.HCl
  • Solubility:
    Soluble to 50 mM in water
  • Storage:
    Store at RT
  • CAS No:
    64208-32-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for CGP 12177 hydrochloride include:

5 Citations: Showing 1 - 5
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  1. Recruitment of β-arrestin 1 and 2 to the β2-adrenoceptor: analysis of 65 ligands.
    Authors: Littmann Et al.
    Proc Natl Acad Sci U S A  2015;355:183
  2. Negative cooperativity across β1-adrenoceptor homodimers provides insights into the nature of the secondary low-affinity CGP 12177 β1-adrenoceptor binding conformation.
    Authors: Gherbi Et al.
    FASEB J  2015;29:2859
  3. Application of BRET to monitor ligand binding to GPCRs.
    Authors: Stoddart Et al.
    Nat Methods  2015;12:661
  4. Oleoylethanolamide enhances β-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat.
    Authors: Suárez Et al.
    Dis Model Mech  2014;7:129
  5. Detection of the secondary, low-affinity β1 -adrenoceptor site in living cells using the fluorescent CGP 12177 derivative BODIPY-TMR-CGP.
    Authors: Gherbi Et al.
    Br J Pharmacol  2014;171:5431

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