CGP 20712 dihydrochloride

  ( 15 citations )    
Product Datasheet
Catalog Number:1024
Chemical Name:1-[2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino]-3-[4-(1-methyl-4-trifluoromethyl-2-imidazolyl)phenoxy]-2-propanol dihydrochloride
Product Details
Citations (15)
Supplemental Products
Reviews
Biological Activity
Highly selective and potent β1-adrenoceptor antagonist (IC50 = 0.7 nM). Displays 10,000-fold selectivity over β2-adrenoceptors. Also available as part of the β-Adrenoceptor Antagonist Tocriset™.
Technical Data
  • M.Wt:
    567.39
  • Formula:
    C23H25F3N4O5.2HCl
  • Solubility:
    Soluble to 50 mM in water
  • Purity:
    >96
  • Storage:
    Desiccate at +4°C
  • CAS No:
    1216905-73-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for CGP 20712 dihydrochloride include:

15 Citations: Showing 1 - 10
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  1. β2-Adrenergic Receptor Antagonism Attenuates CNV Through Inhibition of VEGF and IL-6 Expression.
    Authors: Lavine
    Invest Ophthalmol Vis Sci  2017;58(1):299
  2. Recruitment of β-arrestin 1 and 2 to the β2-adrenoceptor: analysis of 65 ligands.
    Authors: Littmann Et al.
    J Biol Chem  2015;355:183
  3. β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion.
    Authors: Creed Et al.
    Breast Cancer Res  2015;17:145
  4. Galactomannan and Zymosan Block the Epinephrine-Induced Particle Transport in Tracheal Epithelium.
    Authors: Weiterer Et al.
    J Neurochem  2015;10:e0143163
  5. Detection of the secondary, low-affinity β1 -adrenoceptor site in living cells using the fluorescent CGP 12177 derivative BODIPY-TMR-CGP.
    Authors: Gherbi Et al.
    Br J Pharmacol  2014;171:5431
  6. Synthesis and in vitro and in vivo characterization of highly β1-selective β-adrenoceptor partial agonists.
    Authors: Mistry Et al.
    J Med Chem  2013;56:3852
  7. Attenuation of choroidal neovascularization by β(2)-adrenoreceptor antagonism.
    Authors: Lavine Et al.
    JAMA Ophthalmol  2013;131:376
  8. Cardiovascular agents affect the tone of pulmonary arteries and veins in precision-cut lung slices.
    Authors: Rieg Et al.
    PLoS One  2012;6:e29698
  9. Cytoskeletal role in protection of the failing heart by β-adrenergic blockade.
    Authors: Cheng Et al.
    Am J Physiol Heart Circ Physiol  2012;302:H675
  10. Both α1- and β1-adrenoceptors in the bed nucleus of the stria terminalis are involved in the expression of conditioned contextual fear.
    Authors: Hott Et al.
    Br J Pharmacol  2012;167:207
  11. Modulation of calcium-dependent inactivation of L-type Ca2+ channels via β-adrenergic signaling in thalamocortical relay neurons.
    Authors: Rankovic Et al.
    PLoS One  2011;6:e27474
  12. β-Adrenergic receptor stimulation and activation of protein kinase A protect against α1-adrenergic-mediated phosphorylation of protein kinase D and histone deacetylase 5.
    Authors: Sucharov Et al.
    Circulation  2011;17:592
  13. Unchanged β-adrenergic stimulation of cardiac L-type calcium channels in Ca v 1.2 phosphorylation site S1928A mutant mice.
    Authors: Lemke Et al.
    PLoS One  2008;283:34738
  14. Both alpha1 and alpha2-adrenoceptors mediate the cardiovascular responses to noradrenaline microinjected into the bed nucleus of the stria terminal of rats.
    Authors: Crestani Et al.
    Br J Pharmacol  2008;153:583
  15. β 1-adrenergic receptor autoantibodies mediate dilated cardiomyopathy by agonistically inducing cardiomyocyte apoptosis.
    Authors: Jane-Wit Et al.
    J Pharmacol Exp Ther  2007;116:399
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