CGP 20712 dihydrochloride

Catalog # Availability Size / Price Qty
1024/10
1024/50
Adrenergic beta-1 Receptor Antagonists Small Molecule
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Description: Highly potent and selective β1 antagonist

Chemical Name: 1-[2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino]-3-[4-(1-methyl-4-trifluoromethyl-2-imidazolyl)phenoxy]-2-propanol dihydrochloride

Purity: ≥96%

Product Details
Citations (16)
Supplemental Products
Reviews

Biological Activity

Highly selective and potent β1-adrenoceptor antagonist (IC50 = 0.7 nM). Displays 10,000-fold selectivity over β2-adrenoceptors. Also available as part of the β-Adrenoceptor Antagonist Tocriset™.

Technical Data

M.Wt:
567.39
Formula:
C23H25F3N4O5.2HCl
Solubility:
Soluble to 50 mM in water
Purity:
≥96%
Storage:
Desiccate at +4°C
CAS No:
1216905-73-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for CGP 20712 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for CGP 20712 dihydrochloride include:

16 Citations: Showing 1 - 10

  1. β2-Adrenergic Receptor Antagonism Attenuates CNV Through Inhibition of VEGF and IL-6 Expression.
    Authors: Lavine
    Invest Ophthalmol Vis Sci  2017;58(1):299
  2. Modulation of neuroinflammation and pathology in the 5XFAD mouse model of Alzheimer's disease using a biased and selective beta-1 adrenergic receptor partial agonist.
    Authors: Ardestani Et al.
    Neuropharmacology  2017;116:371
  3. Recruitment of β-arrestin 1 and 2 to the β2-adrenoceptor: analysis of 65 ligands.
    Authors: Littmann Et al.
    J Biol Chem  2015;355:183
  4. β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion.
    Authors: Creed Et al.
    Breast Cancer Res  2015;17:145
  5. Galactomannan and Zymosan Block the Epinephrine-Induced Particle Transport in Tracheal Epithelium.
    Authors: Weiterer Et al.
    J Neurochem  2015;10:e0143163
  6. Detection of the secondary, low-affinity β1 -adrenoceptor site in living cells using the fluorescent CGP 12177 derivative BODIPY-TMR-CGP.
    Authors: Gherbi Et al.
    Br J Pharmacol  2014;171:5431
  7. Synthesis and in vitro and in vivo characterization of highly β1-selective β-adrenoceptor partial agonists.
    Authors: Mistry Et al.
    J Med Chem  2013;56:3852
  8. Attenuation of choroidal neovascularization by β(2)-adrenoreceptor antagonism.
    Authors: Lavine Et al.
    JAMA Ophthalmol  2013;131:376
  9. Cardiovascular agents affect the tone of pulmonary arteries and veins in precision-cut lung slices.
    Authors: Rieg Et al.
    PLoS One  2012;6:e29698
  10. Cytoskeletal role in protection of the failing heart by β-adrenergic blockade.
    Authors: Cheng Et al.
    Am J Physiol Heart Circ Physiol  2012;302:H675

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