Catalog Number: 2966
Alternate Names: TCH 346 maleate
Chemical Name: N-(Dibenz[b,f]oxepin-10-ylmethyl)-N-Methyl-N-(2-propynyl)amine maleate
Biological Activity
Orally active glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor. Exhibits antiapoptotic activity via inhibition of GAPDH nuclear translocation and mitochondrial complex 1-dependent H2O2 release. Displays neuroprotective activity in vivo.
Technical Data
  • M.Wt:
    391.42
  • Formula:
    C19H17NO.C4H4O4
  • Solubility:
    Soluble to 10 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    200189-97-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. TCH346 prevents motor symptoms and loss of striatal FDOPA uptake in bilaterally MPTP-treated primates.
    Andringa et al.
    Neurobiol.Dis., 2003;14:205
  2. An orally active anti-apoptotic molecule (CGP 3466B) preserves mitochondria and enhances survival in an animal model of motoneuron disease.
    Sagot et al.
    Br.J.Pharmacol., 2000;131:721
  3. Clorgyline and other propargylamine derivatives as inhibitors of succinate-dependent H2O2 release at NADH:UBIQUINONE oxidoreductase (Complex I) in brain mitochondria.
    Zoccarato et al.
    J.Bioenerg.Biomembr., 2008;40:289

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