CGP 3466B maleate

Tocris Bioscience | Catalog # 2966

GAPDH inhibitor; neuroprotective
Tocris Bioscience

Key Product Details

Description

GAPDH inhibitor; neuroprotective

Alternative Names

TCH 346 maleate
View all Dehydrogenase Inhibitors »

Product Description

CGP 3466B maleate is an orally active glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor. Exhibits antiapoptotic activity via inhibition of GAPDH nuclear translocation and mitochondrial complex 1-dependent H2O2 release. CGP 3466B inhibits colon cancer proliferation in vitro and displays neuroprotective activity in vivo.

Product Specifications for CGP 3466B maleate

Molecular Weight

391.42

Formula

C19H17NO.C4H4O4

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-(Dibenz[b,f]oxepin-10-ylmethyl)-N-Methyl-N-(2-propynyl)amine maleate

CAS Number

200189-97-5

PubChem ID

9821821

InChI Key

SQAZQLMBEHYFJA-BTJKTKAUSA-N

SMILES

O=C(O)/C=C\C(O)=O.CN(CC#C)CC2=CC1=CC=CC=C1OC3=C2C=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 3.91 10
DMSO 39.14 100

Preparing Stock Solutions for CGP 3466B maleate

The following data is based on the product molecular weight 391.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.77 mL 25.55 mL
5 mM 0.51 mL 2.55 mL 5.11 mL
10 mM 0.26 mL 1.28 mL 2.55 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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Product Documents for CGP 3466B maleate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CGP 3466B maleate

For research use only

Related Research Areas

Redox Enzymes

Citations for CGP 3466B maleate

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