CGP 42112 (CAS 127060-75-7): R&D Systems
Catalog Number: 2569
Biological Activity
Selective, high affinity angiotensin AT2 receptor ligand (Ki = 0.24 nM). Displays agonistic properties at proximal tubule AT2 receptors, causes Na+, K+-ATPase inhibition and sodium excretion. Antagonizes Ang-II induced contractions in rabbit aortic rings (IC50 = 1850 nM).
Technical Data
  • M.Wt:
    1052.2
  • Formula:
    C52H69N13O11
  • Sequence:
    YKHPI

    (Modifications: Tyr-1 = N-α-Nicotinoyl, Lys-2 = Lys-(N-α-Z-Arg))

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    127060-75-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The role of angiotensin receptor subtypes in cerebrovascular regulation in the rat.
    Naveri
    Acta.Physiol.Scand.Suppl., 1995;630:1
  2. Angiotensin II AT2 receptors inhibit proximal tubular Na+-K+-ATPase activity via a NO/cGMP-dependent pathway.
    Hakam and Hussain
    Am.J.Physiol.Renal Physiol., 2006;290:F1430
  3. Binding characteristics and vascular effects of various angiotensin II antagonists.
    Criscione et al.
    J.Cardiovas.Pharmacol., 1990;16:S56
Citations:

The citations listed below are publications that use Tocris products. Selected citations for CGP 42112 include:

3 Citations: Showing 1 - 3
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  1. Angiotensin-(1-7) selectively induces relaxation and modulates endothelium-dependent dilation in mesenteric arteries of salt-fed rats
    Authors: Raffai Et al.
    Journal of Vascular Research 2016;53:105
  2. Perinatal nicotine exposure increases vulnerability of hypoxic-ischemic brain injury in neonatal rats: role of angiotensin II receptors.
    Authors: Li Et al.
    BMC Cancer 2012;43:2483
  3. Regulation of angiotensin II type 2 receptor gene expression in the adrenal medulla by acute and repeated immobilization stress.
    Authors: Nostramo Et al.
    Stroke 2012;215:291

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