Selective, high affinity angiotensin AT2
receptor ligand (Ki
= 0.24 nM). Displays agonistic properties at proximal tubule AT2
receptors, causes Na+
-ATPase inhibition and sodium excretion. Antagonizes Ang-II induced contractions in rabbit aortic rings (IC50
= 1850 nM).
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The role of angiotensin receptor subtypes in cerebrovascular regulation in the rat.
Angiotensin II AT2 receptors inhibit proximal tubular Na+-K+-ATPase activity via a NO/cGMP-dependent pathway.
Hakam and Hussain
Am.J.Physiol.Renal Physiol., 2006;290:F1430
Binding characteristics and vascular effects of various angiotensin II antagonists.
Criscione et al.
The citations listed below are publications that use Tocris products. Selected citations for CGP 42112 include:
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