Biological ActivityCGP 42112 is a selective, high affinity angiotensin AT2 receptor ligand (Ki = 0.24 nM). Displays agonistic properties at proximal tubule AT2 receptors, causes Na+, K+-ATPase inhibition and sodium excretion. Antagonizes Ang-II induced contractions in rabbit aortic rings (IC50 = 1850 nM).
(Modifications: Tyr-1 = N-α-Nicotinoyl, Lys-2 = Lys-(N-α-Z-Arg))
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The role of angiotensin receptor subtypes in cerebrovascular regulation in the rat.
Angiotensin II AT2 receptors inhibit proximal tubular Na+-K+-ATPase activity via a NO/cGMP-dependent pathway.
Hakam and Hussain
Am.J.Physiol.Renal Physiol., 2006;290:F1430
Binding characteristics and vascular effects of various angiotensin II antagonists.
Criscione et al.
Citations for CGP 42112
The citations listed below are publications that use Tocris products. Selected citations for CGP 42112 include:
3 Citations: Showing 1 - 3
Angiotensin-(1-7) selectively induces relaxation and modulates endothelium-dependent dilation in mesenteric arteries of salt-fed rats
Authors: Raffai Et al.
Journal of Vascular Research 2016;53:105
Perinatal nicotine exposure increases vulnerability of hypoxic-ischemic brain injury in neonatal rats: role of angiotensin II receptors.
Authors: Li Et al.
BMC Cancer 2012;43:2483
Regulation of angiotensin II type 2 receptor gene expression in the adrenal medulla by acute and repeated immobilization stress.
Authors: Nostramo Et al.
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