CGP 42112

Catalog # Availability Size / Price Qty
2569/1
CGP 42112
1 Image
Description: Selective, high affinity AT2 ligand
Product Details
Citations (3)
Supplemental Products
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Biological Activity

Selective, high affinity angiotensin AT2 receptor ligand (Ki = 0.24 nM). Displays agonistic properties at proximal tubule AT2 receptors, causes Na+, K+-ATPase inhibition and sodium excretion. Antagonizes Ang-II induced contractions in rabbit aortic rings (IC50 = 1850 nM).

Technical Data

M.Wt:
1052.2
Formula:
C52H69N13O11
Sequence:
YKHPI

(Modifications: Tyr-1 = N-α-Nicotinoyl, Lys-2 = Lys-(N-α-Z-Arg))

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
127060-75-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The role of angiotensin receptor subtypes in cerebrovascular regulation in the rat.
    Naveri
    Acta.Physiol.Scand.Suppl., 1995;630:1
  2. Angiotensin II AT2 receptors inhibit proximal tubular Na+-K+-ATPase activity via a NO/cGMP-dependent pathway.
    Hakam and Hussain
    Am.J.Physiol.Renal Physiol., 2006;290:F1430
  3. Binding characteristics and vascular effects of various angiotensin II antagonists.
    Criscione et al.
    J.Cardiovas.Pharmacol., 1990;16:S56

Product Datasheets

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Citations for CGP 42112

The citations listed below are publications that use Tocris products. Selected citations for CGP 42112 include:

3 Citations: Showing 1 - 3

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