CGP 42112

  ( 3 citations )    
Product Datasheet
Catalog Number:2569
Chemical Name:
Product Details
Citations (3)
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Biological Activity
Selective, high affinity angiotensin AT2 receptor ligand (Ki = 0.24 nM). Displays agonistic properties at proximal tubule AT2 receptors, causes Na+, K+-ATPase inhibition and sodium excretion. Antagonizes Ang-II induced contractions in rabbit aortic rings (IC50 = 1850 nM).
Technical Data
  • M.Wt:
    1052.2
  • Formula:
    C52H69N13O11
  • Sequence:
    YKHPI

    (Modifications: Tyr-1 = N-α-Nicotinoyl, Lys-2 = Lys-(N-α-Z-Arg))

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    127060-75-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for CGP 42112 include:

3 Citations: Showing 1 - 3
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  1. Angiotensin-(1-7) selectively induces relaxation and modulates endothelium-dependent dilation in mesenteric arteries of salt-fed rats
    Authors: Raffai Et al.
    Journal of Vascular Research  2016;53:105
  2. Perinatal nicotine exposure increases vulnerability of hypoxic-ischemic brain injury in neonatal rats: role of angiotensin II receptors.
    Authors: Li Et al.
    BMC Cancer  2012;43:2483
  3. Regulation of angiotensin II type 2 receptor gene expression in the adrenal medulla by acute and repeated immobilization stress.
    Authors: Nostramo Et al.
    Stroke  2012;215:291

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