CGP 52411

   
Product Datasheet
Catalog Number:3360
Alternate Names:DAPH
Chemical Name:5,6-Bis(phenylamino)-1H-isoindole-1,3(2H)-dione
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Biological Activity
Selective inhibitor of the epidermal growth factor receptor (EGFR) (IC50 = 0.3 μM in vitro). Also inhibits and reverses the formation of Aβ42 fibers associated with Alzheimer's disease. Eliminates calcium influx potential when coincubated with amyloid β-peptide (1-42) (Cat.No. 1428); reduces neurotoxicity by blocking Ca2+ influx into neuronal cells.
Technical Data
  • M.Wt:
    329.35
  • Formula:
    C20H15N3O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    145915-58-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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