Chemical Name: 5,6-Bis(phenylamino)-1H-isoindole-1,3(2H)-dione
Biological ActivitySelective inhibitor of the epidermal growth factor receptor (EGFR) (IC50 = 0.3 μM in vitro). Also inhibits and reverses the formation of Aβ42 fibers associated with Alzheimer's disease. Eliminates calcium influx potential when coincubated with amyloid β-peptide (1-42) (Cat.No. 1428); reduces neurotoxicity by blocking Ca2+ influx into neuronal cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
4,5-dianilinophthalimide: a protein tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent in vivo antitumor activity.
Buchdunger et al.
Efficient reversal of Alzheimer's disease fibril formation and elimination of neurotoxicity by a small molecule.
Blanchard et al.
Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs.
Wang et al.
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VersaClone cDNA Plasmids
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