CGP 52411
Chemical Name: 5,6-Bis(phenylamino)-1H-isoindole-1,3(2H)-dione
Purity: ≥99%
Biological Activity
CGP 52411 is a selective inhibitor of the epidermal growth factor receptor (EGFR) (IC50 = 0.3 μM in vitro). Also inhibits and reverses the formation of Aβ42 fibers associated with Alzheimer's disease. Eliminates calcium influx potential when coincubated with amyloid β-peptide (1-42) (Cat.No. 1428); reduces neurotoxicity by blocking Ca2+ influx into neuronal cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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4,5-dianilinophthalimide: a protein tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent in vivo antitumor activity.
Buchdunger et al.
Proc.Natl.Acad.Sci., 1994;91:2334 -
Efficient reversal of Alzheimer's disease fibril formation and elimination of neurotoxicity by a small molecule.
Blanchard et al.
Proc.Natl.Acad.Sci., 2004;101:14326 -
Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs.
Wang et al.
Proc.Natl.Acad.Sci., 2008;105:7159
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