Amyloid β-Peptide (1-42) (human)

Tocris Bioscience | Catalog # 1428

Predominant amyloid β-protein fragment
Tocris Bioscience

Key Product Details

Description

Predominant amyloid β-protein fragment
View all Amyloid beta Peptides »

Product Description

Amyloid β-Peptide (1-42) (human) is a human form of the predominant amyloid β-peptide found in the brains of patients with Alzheimer's disease. Downregulates bcl-2 and increases the levels of bax. Neurotoxic.

Control Peptide also available.

Product Specifications for Amyloid β-Peptide (1-42) (human)

Molecular Weight

4514.08

Formula

C203H311N55O60S

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

107761-42-2

PubChem ID

16135558

InChI Key

DZHSAHHDTRWUTF-SIQRNXPUSA-N

SMILES

[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 1mg/ml in 50mM Tris buffer

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 27 publications citing the usage of this product.

Product Documents for Amyloid β-Peptide (1-42) (human)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Amyloid β-Peptide (1-42) (human)

For research use only

Citations for Amyloid β-Peptide (1-42) (human)

Customer Reviews for Amyloid β-Peptide (1-42) (human) (1)

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  • Great product for inflammation testing.
    Name: Eric Dyne
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Microglia
    Verified Customer | Posted 09/24/2020
    I used a stationary incubator at 30C and a mixture in an upcoming manuscript that promoted optimal aggregation that was reproducible. I did not use DMSO or water but a special phosphate buffer with alkaline solution.
    I used this peptide to induce aggregation along with several other brands. The tocris beta-amyloid reacted the best with Thioflavin-T (1uM) in my experience however, I did find the bachem sample seemed to have the best aggregation patterns.
    Amyloid β-Peptide (1-42) (human) 1428

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